647860-10-4Relevant academic research and scientific papers
Synthesis of 5-(4-alkylsulfanyl-[1,2,5]thiadiazol-3-yl)-3-methyl-1,2,3, 4-tetrahydropyrimidine oxalate salts and their evaluation as muscarinic receptor agonists
Jung, Myung Hee,Park, Jewn-Giew,Park, Woo-Kyu
, p. 230 - 235 (2007/10/03)
The synthesis and biological test of 5-(4-alkylsulfanyl-[1,2,5]thiadiazol-3-yl)-3-methyl-1,2,3, 4-tetrahydropyrimidine oxalate salts 7 as muscarinic receptor agonists are described. The key intermediate 4 was obtained by a modified Strecker reaction and cyclization, and the 3-methyl-1,2,3,4-tetrahydropyrimidines were obtained by subsequent substitution, quarternization, and reduction. The final products 7 were obtained as oxalic acid salts. The prepared compounds were examined in vitro for their binding affinities to the cloned human muscarinic receptor by the [3H]-NMS binding assay.
