647862-95-1

Basic information

• Product Name: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene
• Synonyms: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene;2-Bromo-4,5-difluorobenzyl bromide
• CAS NO: 647862-95-1
• Molecular Formula: C₇H₄Br₂F₂
• Molecular Weight: 285.9114664
• Mol File: 647862-95-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene(647862-95-1)
• EPA Substance Registry System: 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene, alpha,2-Dibromo-4,5-difluorotoluene(647862-95-1)

Safety Data

• Hazardous Substances Data: 647862-95-1(Hazardous Substances Data)

Usage

General Description

"1-Bromo-2-(bromomethyl)-4,5-difluorobenzene" and "alpha,2-Dibromo-4,5-difluorotoluene" are both aromatic compounds containing bromine and fluorine atoms. 1-Bromo-2-(bromomethyl)-4,5-difluorobenzene is a benzene derivative with one bromine atom and two bromomethyl groups attached to the benzene ring, as well as two fluorine atoms. Alpha,2-Dibromo-4,5-difluorotoluene, on the other hand, is a toluene derivative with two bromine atoms attached to the benzene ring and two fluorine atoms in the 4 and 5 positions. Both compounds are used in the production of pharmaceuticals, agrochemicals, and other specialty chemicals due to their unique chemical properties and reactivity.

Upstream product

• 875664-38-3 1-bromo-4,5-difluoro-2-methylbenzene 
• 476620-55-0 (2-bromo-4,5-difluorophenyl)methanol 
• 64695-84-7 2-bromo-4,5-difluorobenzoic acid 

Downstream Products

• 1017581-66-6 (2-bromo-4,5-difluorophenyl)acetonitrile 

Relevant articles and documents

Cross-coupling strategy for the synthesis of diazocines

Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.

Synthesis of benzylisoquinoline derivatives possessing electron-withdrawing substituents on the benzene ring of the isoquinoline skeleton

3,4-Dihydrobenzylisoquinolines and 1,2,3,4-tetrahydrobenzyl-isoquinolines possessing electron withdrawing substituents on the benzene ring of the isoquinoline framework are easily accessible by a synthetic approach that takes advantage of a Sonogashira coupling to build up the C1-C8a bond of the isoquinoline skeleton and a Ti-catalyzed intramolecular hydroamination of an alkyne to close the heterocyclic ring.

PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.