647863-16-9

Upstream product

• 76-83-5 trityl chloride 
• 64051-79-2 piperidin-3-ol hydrochloride 
• 6859-99-0 3-hydroxypiperazine 

Downstream Products

• 1271239-87-2 2-(adenin-9-yl)methyl-1-N-tritylpyrrolidine 
• 1271239-78-1 (RS)-3-(adenin-9-yl)-1-N-tritylpiperidine 
• 1271239-90-7 (RS)-3-(cytosin-2-O-yl)-1-N-tritylpiperidine 
• 1271239-83-8 2-(thymin-1-yl)methyl-1-N-tritylpyrrolidine 
• 1271239-96-3 (RS)-3-(thymin-1-yl)-1-N-tritylpiperidine 
• 124256-80-0 (RS)-3-mesyloxy-1-N-tritylpiperidine 
• 73962-46-6 1-N-trityl-1,2,3,6-tetrahydropyridine 
• 1271239-68-9 (RS)-3-(6-chloropurin-9-yl)-1-N-tritylpiperidine 
• 1271239-73-6 (RS)-3-(2-amino-6-chloropurin-9-yl)-1-N-tritylpiperidine 

Relevant academic research and scientific papers

The synthesis of piperidine nucleoside analogs - A comparison of several methods to access the introduction of nucleobases

This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found.

PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.