64801-78-1

Basic information

• Product Name: 2-Imidazolidinethione, 4-(phenylmethyl)-
• CAS NO: 64801-78-1
• Molecular Formula: C10H12N2S
• Molecular Weight: 192.285
• Mol File: 64801-78-1.mol

Chemical Properties

• CAS DataBase Reference: 2-Imidazolidinethione, 4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Imidazolidinethione, 4-(phenylmethyl)-(64801-78-1)
• EPA Substance Registry System: 2-Imidazolidinethione, 4-(phenylmethyl)-(64801-78-1)

Safety Data

• Hazardous Substances Data: 64801-78-1(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 75543-73-6 (S)-2-amino-3-phenyl-1-propylamine 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Downstream Products

• 889097-64-7 C₁₃H₁₆N₂S*ClH 
• 889097-61-4 C₁₈H₂₀N₂OS*ClH 

Relevant articles and documents

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

New histamine H3-receptor antagonists were synthesised and tested on rat brain membranes and on electrically stimulated guinea-pig ileum. The new compounds have a central polar group represented by a 2-alkylimidazole or a 2-thioimidazoline nucleus. The effect of the polar group basicity on the optimal length of the alkyl chain, connecting this group to a 4(5)-imidazolyl ring, was investigated. The best affinity values, obtained by displacement of [3H]-RAMHA from rat brain, were obtained for the 2-alkylimidazole derivatives (2a-f) with tetramethylene chain (pK(i) 8.03-8.97), having an intermediate basicity between that of the previously reported 2- thioimidazoles (1a-i) and that of 2-alkylthioimidazolines (3a-h). In contrast, a general lowering of affinity (pK(i) 5.90-7.63) was observed for compounds of the last series (3a-h), with a complex dependence on the terminal lipophilic group and chain length. (C) 2000 Elsevier Science S.A.

IMIDAZOLINE DERIVATIVES AS CXCR4 MODULATORS

The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as CXCR4 modulators that specifically target the CXCR4 minor pocket, and they have further been

Method of making imidazole-2-thiones

The present invention provides a method of making an imidazole-2-thione which comprises the steps of reacting a vicinal diamine with a compound having a thiocarbonyl moiety and oxidizing the resulting reaction product to obtain said imidazole-2-thione.