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1-Methylhistamine Dihydrochloride is a significant metabolite of histamine, formed through the action of histamine N-methyltransferase in the histidine metabolism pathway. It serves as a crucial biomarker for assessing the activity of the histaminergic system in the brains of patients with various neurological conditions, including Alzheimer's disease, hypersomnia, and others.

6481-48-7

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6481-48-7 Usage

Uses

Used in Pharmaceutical Industry:
1-Methylhistamine Dihydrochloride is used as a selective H1-receptor agonist for its ability to modulate histamine receptors, which play a vital role in various physiological processes such as immune response, sleep-wake regulation, and allergic reactions.
Used in Neurological Research:
1-Methylhistamine Dihydrochloride is used as a biomarker for assessing the histaminergic system activity in the brains of patients with neurological conditions like Alzheimer's disease, hypersomnia, and others. This helps in understanding the underlying mechanisms and potential therapeutic targets for these conditions.
Used in Sleep Research:
Due to its depressant effects, 1-Methylhistamine Dihydrochloride is used in sleep research to study the role of histamine in the regulation of sleep-wake cycles and to develop potential treatments for sleep disorders.
Used in Allergy Research:
1-Methylhistamine Dihydrochloride is used as a research tool to investigate the role of histamine in allergic reactions and to develop new therapeutic strategies for allergic diseases by targeting histamine receptors.

Biochem/physiol Actions

Major metabolite of histamine by histamine N-methyltransferase.

Check Digit Verification of cas no

The CAS Registry Mumber 6481-48-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,8 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6481-48:
(6*6)+(5*4)+(4*8)+(3*1)+(2*4)+(1*8)=107
107 % 10 = 7
So 6481-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3

6481-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N1-Methylhistamine dihydrochloride

1.2 Other means of identification

Product number -
Other names 1-METHYLHISTAMINE DIHYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6481-48-7 SDS

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