64813-80-5Relevant articles and documents
Total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C
Li, Chao,Tu, Shanghui,Wen, Shuguang,Li, Shan,Chang, Junbiao,Shao, Feng,Lei, Xiaoguang
, p. 3566 - 3570 (2011)
A concise total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C is reported using a 1,4-addition-aldol condensation-ring-closing metathesis (RCM) strategy. Initial biological studies indicate that psilostachyin C could enhance the sensitivity of the HeLa cell toward camptothecin (CPT) treatment via the activation of the caspase-3 mediated apoptosis pathway.
