64820-43-5

Basic information

• Product Name: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine
• Synonyms: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine
• CAS NO: 64820-43-5
• Molecular Formula: C₂₁H₁₆ClNS
• Molecular Weight: 349.87644
• Mol File: 64820-43-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(64820-43-5)
• EPA Substance Registry System: 4-(4-chlorophenyl)-2-phenyl-2,3-dihydro-1,5-benzothiazepine(64820-43-5)

Safety Data

• Hazardous Substances Data: 64820-43-5(Hazardous Substances Data)

Upstream product

• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 137-07-5 2-amino-benzenethiol 
• 956-02-5 4'-chlorochalcone 
• 60246-64-2 β-(2-Aminophenylmercapto)-β-phenyl-propiophenone 
• 40358-31-4 2,3-dihydro-2,4-diphenyl-1,5-benzothiazepine 

Downstream Products

• 1371262-47-3 2a-(4-chlorophenyl)-2-phenoxy-4-phenyl-2,2a,3,4-tetrahydro-1H-azeto[2,1-d][1,5]benzothiazepin-1-one 

Relevant articles and documents

A practical synthesis of 2,3-dihydro-1,5-benzothiazepines

2,3-Dihydro-1,5-benzothiazepines have been obtained through a domino process involving a Michael addition of 2-aminothiophenols to chalcones, followed by in situ cyclization. Up to 98% chemical yields have been obtained at room temperature under essential

Syntheses of potentially bioactive [1,2,4]oxadiazolo[5,4-d]benzothiazepines by 1,3-dipolar cycloaddition

The chalcones, 2a-2l reacted with o-aminobenzenthiol to give a series of 1,5-benzothiazepines, 3a-3l. The [3+2] 1, 3-dipolar cycloaddition reactions of 3a-3l with ethyl chlorooximidoacetate in the presence of Et3N afforded the target compounds, 4a-4l possessing an additional 1,2,4-oxadiazole ring fused to the heptaatomic nucleus. The structures have been elucidated by spectral methods and X-ray crystallographic analysis.

'On water' synthesis of 2,4-diaryl-2,3-dihydro-1,5-benzothiazepines catalysed by sodium dodecyl sulfate (SDS)

An efficient synthesis of 1,3-diaryl-2,3-dihydro-1,5-benzothiazepines has been developed by the reaction of various 1,3-diaryl-2-propenones with 2-aminothiophenol in water under neutral conditions catalysed by SDS. Excellent chemoselectivity was observed for substrates possessing halogen atoms or nitro/alkoxy/thioalkyl groups which did not undergo competitive aromatic nucleophilic substitution of the halogen atoms or the nitro group, reduction of the nitro or the α,β-unsaturated carbonyl group, or dealkylation of the alkoxy/thioalkoxy groups.