648414-76-0Relevant articles and documents
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Duan, James J.-W.,Lu, Zhonghui,Xue, Chu-Biao,He, Xiaohua,Seng, Jennifer L.,Roderick, John J.,Wasserman, Zelda R.,Liu, Rui-Qin,Covington, Maryanne B.,Magolda, Ronald L.,Newton, Robert C.,Trzaskos, James M.,Decicco, Carl P.
, p. 2035 - 2040 (2007/10/03)
New inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered using an N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamide scaffold. The series was found to be potent in a porcine TACE (pTACE) assay with IC50s typically below 5 nM.