648422-42-8

Basic information

• Product Name: 6-METHYL-NICOTINIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER
• Synonyms: 6-METHYL-NICOTINIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER
• CAS NO: 648422-42-8
• Molecular Formula: C11H10N2O4
• Molecular Weight: 234.21
• Mol File: 648422-42-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-METHYL-NICOTINIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-NICOTINIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER(648422-42-8)
• EPA Substance Registry System: 6-METHYL-NICOTINIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER(648422-42-8)

Safety Data

• Hazardous Substances Data: 648422-42-8(Hazardous Substances Data)

Upstream product

• 3222-47-7 6-methylnicotinic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 

Relevant articles and documents

Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

Methyl groups of 6-methylnicotinic acid and 2,6-dimethylnicotinic acid were deuterated by an H-D exchange reaction under conditions of 1% NaOD/D(2)O on heating. With a condensation reaction between the D-labeled nicotinic acid derivative and N-hydroxysuccinimide with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, the nicotinoylating agents, 1-(6-methyl[D(3)]nicotinoyloxy)succinimide (2c) and 1-(2,6-dimethyl[D(6)]nicotinoyloxy)succinimide (2f) were prepared. Both D-labeled nicotinoylating agents and their unlabeled counterparts quantitatively modified the N-terminal of protein.