648428-08-4

Basic information

• Product Name: Oxazole, 2-ethyl-4,5-dihydro-4-(1-methylethyl)-, (4R)-
• CAS NO: 648428-08-4
• Molecular Formula: C8H15NO
• Molecular Weight: 141.213
• Mol File: 648428-08-4.mol

Chemical Properties

• CAS DataBase Reference: Oxazole, 2-ethyl-4,5-dihydro-4-(1-methylethyl)-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 2-ethyl-4,5-dihydro-4-(1-methylethyl)-, (4R)-(648428-08-4)
• EPA Substance Registry System: Oxazole, 2-ethyl-4,5-dihydro-4-(1-methylethyl)-, (4R)-(648428-08-4)

Safety Data

• Hazardous Substances Data: 648428-08-4(Hazardous Substances Data)

Upstream product

• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 115-80-0 Triethyl orthopropionate 

Downstream Products

• 189040-53-7 (4R)-2,4-diisopropyl-4,5-dihydrooxazole 

Relevant articles and documents

New Synthesis of Optically Active 5-Isoxazolidinones and β-Amino Acids

A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of β-amino acids.

Synthesis of Enantiomerically Enriched Oxazolinyl[1,2]Oxazetidines

The first stereoselective synthesis of oxazolinyl[1,2]oxazetidines based on the reaction of lithiated 2-(1-chloroethyl)-2-oxazolines with nitrones is described. Highly enantioenriched oxazolinyl[1,2]oxazetidines have also been prepared starting from a 1:1 diastereomeric mixture of optically active 2-(1-chloroethyl)-2-oxazolines.