(4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:(4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole
CAS No.:648428-08-4
Molecular Formula:C8H15NO
Molecular Weight:141.213
Hs Code.:
DSSTox Substance ID:DTXSID30514564
Wikidata:Q82374956

Synonyms:648428-08-4;(4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole;DTXSID30514564

Suppliers and Price of (4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:141.115364102
Heavy Atom Count:10
Complexity:140

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NC(CO1)C(C)C
Isomeric SMILES:CCC1=N[C@@H](CO1)C(C)C

Technology Process of (4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole

There total 1 articles about (4R)-2-Ethyl-4-(propan-2-yl)-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4276-09-9,473-75-6
(R)-2-amino-3-methylbutanol

: 115-80-0
Triethyl orthopropionate

: 648428-08-4
(4R)-2-ethyl-4-isopropyl-2-oxazoline

Guidance literature:: In 1,2-dichloro-ethane; at 70 ℃;
DOI:10.1021/jo035356i DOI:10.1021/jo035360u

Reference yield: 90.0%

: 648428-08-4
(4R)-2-ethyl-4-isopropyl-2-oxazoline

: 74-88-4
methyl iodide

: 189040-53-7
(4R)-2,4-diisopropyl-4,5-dihydrooxazole

Guidance literature:: (4R)-2-ethyl-4-isopropyl-2-oxazoline; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo035356i

Reference yield:

: 648428-08-4
(4R)-2-ethyl-4-isopropyl-2-oxazoline

: (4R)-2-[(3R,4S)-2-tert-butyl-3-(4-chlorophenyl)-4-methyl[1,2]oxazetidin-4-yl]-4-isopropyl-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / tert-butyl hypochlorite / CH₂Cl₂ / 0 °C

2.1: LDA / tetrahydrofuran / 0.33 h / -98 °C

2.2: 90 percent / tetrahydrofuran / 3 h / -98 - 20 °C

With tert-butylhypochlorite; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo035360u