64843-16-9

Basic information

• Product Name: 2-Oxazolidinone, 4-hydroxy-3-(phenylmethyl)-
• CAS NO: 64843-16-9
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• Mol File: 64843-16-9.mol

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 4-hydroxy-3-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 4-hydroxy-3-(phenylmethyl)-(64843-16-9)
• EPA Substance Registry System: 2-Oxazolidinone, 4-hydroxy-3-(phenylmethyl)-(64843-16-9)

Safety Data

• Hazardous Substances Data: 64843-16-9(Hazardous Substances Data)

Upstream product

• 107-20-0 2-chloroethanal 
• 124-38-9 carbon dioxide 
• 100-46-9 benzylamine 
• 298-14-6 potassium hydrogencarbonate 
• 17153-05-8 N-benzyl-oxazolidine-2,4-dione 
• 3967-54-2 4-chloro-1,3-dioxolan-2-one 

Downstream Products

• 64843-25-0 3-benzyloxazol-2(3H)-one 
• 1338438-30-4 1-benzyl-8-methoxy-4-[4-(trifluoromethyl)phenyl]oxazolo[5,4-c]quinolin-2(1H)-one 

Relevant articles and documents

OXAZOLO[5,4-C]QUINOLIN-2-ONE COMPOUNDS AS BROMODOMAIN INHIBITORS

The present invention relates to compounds useful as bromodomain inhibitors. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compounds and compositions in the treatment of various diseases and disorders.

Synthesis of bicyclic thiazolidinethiones and oxazolidinones by water-mediated multicomponent reactions (MCR) and ring-closing metathesis (RCM)

Starting with the development of new multicomponent reactions (MCR) in water, hydroxy thiazolidinethiones and oxazolidinones were prepared efficiently in a one-pot procedure. The reaction was carried out under mild conditions, consistent with the principles of green chemistry . These precursors were converted into different dienes containing terminal C-C double bonds by modifying the hydroxy group in one- or two-step sequences. A final ring-closing metathesis (RCM) reaction led to various classes of unsaturated bicycles. New multicomponent reactions (MCR) were developed to form hydroxy thiazolidinethiones and oxazolidinones in one-pot procedures under mild conditions using water as solvent. The hydroxy group was functionalized to give terminal dienes. These species were transformed into unsaturated bicycles containing different carbocyclic and heterocyclic elements by ring-closing metathesis (RCM). Copyright

New heterocyclic inputs for the povarov multicomponent reaction

Oxa-, thia- and imidazolones are reactive inputs as electron-rich olefin components in Povarov reactions. On interaction with anilines and aldehydes, these substrates afford the corresponding multicomponent adducts in a regioselective manner. Intramolecular processes are also explored. Post-condensation oxidation provides convenient access to a variety of fused quinoline derivatives. Georg Thieme Verlag Stuttgart ? New York.