64846-61-3Relevant articles and documents
In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor
Kandasamy, Mohanraj,Huang, Yu- Hsuan,Ganesan, Balaji,Senadi, Gopal Chandru,Lin, Wei-Yu
, p. 4349 - 4356 (2019/07/03)
A highly efficient and convenient Negishi cross-coupling reaction has been developed for the synthesis of unsymmetrical alkynes and enynes in a continuous-flow process. The reaction proceeds through an in situ generated alkynylzinc reagent by the reaction of lithium acetylide with zinc halide at room temperature followed by a cross-coupling reaction with aryl or vinyl iodides. The notable features of this work compared to the conventional benchtop method are mild reaction conditions, good to excellent yields, broad functional-group compatibility, short residence time (73 sec) and especially desilylation of TMS group with the residence time of only 10.5 sec.
Direct preparation of arylethynylzinc bromides and their application to cross-coupling reactions
Joo, Seong-Ryu,Kim, Jong-Sung,Kim, Seung-Hoi
, p. 3267 - 3270 (2017/07/27)
A novel synthetic protocol for the preparation of arylethynylzinc bromides has been developed. Thus-obtained organozinc reagents were successfully employed in the subsequent cross-coupling reactions with a broad range of aryl halides providing the corresponding alkynylated compounds in good to excellent yields.
Negishi cross-coupling reaction as a simple and efficient route to functionalized amino and alkoxy carbene complexes of chromium, molybdenum, and Tungsten
Tobrman, Tom,Jurskov, Ivana,Dvok, Dalimil
, p. 6593 - 6603 (2015/02/19)
Synthesis of functionalized phenyl, 2-thienyl, and N-methyl-pyrrol-2-yl Fischer carbene complexes of chromium and tungsten was achieved via a Negishi cross-coupling reaction of metalated aminocarbenes in the presence of a palladium catalyst. The reverse a
