Technology Process of CID 15974059
There total 3 articles about CID 15974059 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
iodine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
DOI:10.1039/c3cc46570e
- Guidance literature:
-
phenylacetylene;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 0.25h;
zinc dibromide;
In
tetrahydrofuran;
at -78 - 0 ℃;
DOI:10.1002/jhet.1938
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triphenylphosphine; palladium diacetate / tetrahydrofuran; hexane / 80 °C / Flow reactor
2.1: potassium carbonate / tetrahydrofuran; methanol / 20 °C / Flow reactor
3.1: n-butyllithium / tetrahydrofuran; hexane / 20 °C / Flow reactor
3.2: 20 °C / Flow reactor
With
n-butyllithium; palladium diacetate; potassium carbonate; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane;
1.1: |Negishi Coupling;
DOI:10.1002/ejoc.201900471
