64859-37-6

Basic information

• Product Name: Benzene, 1,1'-(2-bromo-2-fluorocyclopropylidene)bis-
• CAS NO: 64859-37-6
• Molecular Formula: C15H12BrF
• Molecular Weight: 291.163
• Mol File: 64859-37-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(2-bromo-2-fluorocyclopropylidene)bis-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(2-bromo-2-fluorocyclopropylidene)bis-(64859-37-6)
• EPA Substance Registry System: Benzene, 1,1'-(2-bromo-2-fluorocyclopropylidene)bis-(64859-37-6)

Safety Data

• Hazardous Substances Data: 64859-37-6(Hazardous Substances Data)

Upstream product

• 530-48-3 1,1-Diphenylethylene 
• 1868-53-7 dibromofluoromethane 

Downstream Products

• 56701-13-4 (2-fluorocyclopropane-1,1-diyl)dibenzene 

Relevant articles and documents

TMSCFX2(X = Cl, Br) as halofluorocarbene sources for the synthesis of halofluorocyclopropanes

TMSCFX2 (X = Cl, Br; TMS = trimethylsilyl) have been developed as halofluorocarbene (CFX, X = Cl, Br) precursors for [2+1] cyclopropanation with alkenes. Structurally diverse halofluorocyclopropanes were obtained in good to excellent yields. It was found

Copper-catalyzed ligand free ring-opening amination of gem-fluorohalocyclopropanes – An efficient route toward 2-fluoroallylamines

Ring-opening amination of gem-chlorofluoro- and gem-bromofluorocyclopropanes with secondary alkyl, aryl amines or hydroxylamines catalyzed by copper(I) or copper(II) compounds with no additional ligands affords tertiary 2-fluoroallylamines or hydroxylamines in moderate to excellent yields. The reaction pathway involves isomerization of gem-fluorohalocyclopropanes to 2-fluoroallyl halides followed by in situ nucleophilic substitution of a halide by an N-nucleophile. The p-methoxyphenyl (PMP) protective group is efficient in the preparation of secondary 2-fluoroallylamines by this method. Primary 2-fluoroallylamines can only be obtained by a stepwise protocol including CuX-catalyzed isomerization of gem-fluorohalocyclopropanes to 2-fluoroallylic halides followed by amination.