6487-33-8

Basic information

• Product Name: (-)-isocorypalmine
• CAS NO: 6487-33-8
• Molecular Weight: 341.407
• Mol File: 6487-33-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (-)-isocorypalmine(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-isocorypalmine(6487-33-8)
• EPA Substance Registry System: (-)-isocorypalmine(6487-33-8)

Safety Data

• Hazardous Substances Data: 6487-33-8(Hazardous Substances Data)

Usage

General Description

(-)-Isocorypalmine is a naturally occurring alkaloid found in multiple plant species, including the genus Corydalis. It has been identified as a potential therapeutic agent for various medical conditions due to its interactions with biological targets such as serotonin and dopamine receptors. Research suggests that (-)-isocorypalmine may have potential for the treatment of conditions such as schizophrenia, addiction, and neurological disorders. In addition, it has also been studied for its potential analgesic and anti-inflammatory effects. As a result, (-)-isocorypalmine has garnered interest from the pharmaceutical industry as a potential source for the development of novel drug compounds. Further research is needed to fully understand the pharmacological properties and potential therapeutic uses of (-)-isocorypalmine.

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Relevant articles and documents

TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION

The present invention provides a tetrahydroprotoberberine compound represented by the formula (I), enantiomers, diastereomers, racemates and mixtures thereof, and pharmaceutically acceptable salts, crystalline hydrates and solvates thereof. The invention also provides a method for preparing the compound and the use thereof in the preparation of a medicament for preventing and/or treating central nervous system diseases.

Tetrahydropalmatine derivative and preparation method and application thereof

The invention discloses a compound and a preparation method and application thereof. The compound is a compound shown in the formula I or stereisomer, geometric isomer, tautomer, nitrogen oxide, hydrate solvate, metabolite and pharmaceutically-acceptable salt or prodrug of the compound shown in the formula I. The compound is a tetrahydropalmatine derivative. The compound has the application in preparing medicine. The medicine can remarkably restrain proliferation of eucaryon tumor cells and/or treat or prevent tumors. The formula I is shown in the specification.

A divergent route to 9,10-oxygenated tetrahydroprotoberberine and 8-oxoprotoberberine alkaloids: Synthesis of (±)-isocorypalmine and oxypalmatine

A new route, which is germane to the synthesis of 9,10-oxygenated tetrahydroprotoberberines and 8-oxoprotoberberines is described. The route features the use of a diester (14) generated from reaction of dimethylmalonate with an aryl halide in the presence of n-butyllithium. The amide 17 prepared in subsequent steps is a versatile precursor for the synthesis of tetrahydroprotoberberine and 8-oxoprotoberberine scaffolds using standard high-yielding reactions. In this manner, (±)-isocorypalmine and oxypalmatine have been synthesized in 23% and 22% yields, respectively.