518-90-1

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dimethoxyphthalic acid is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Dye Industry:
In the dye industry, 3,4-dimethoxyphthalic acid is utilized as a key component in the production of dyes, enhancing color properties and stability in various applications.
Used in Organic Compounds Synthesis:
3,4-Dimethoxyphthalic acid is used as a building block in the synthesis of organic compounds, enabling the creation of a wide range of chemical products with diverse applications.
Used in Polymer and Resin Synthesis:
As a building block in polymer and resin synthesis, 3,4-dimethoxyphthalic acid is employed to improve the properties of these materials, such as strength, durability, and resistance to environmental factors.
Used in Materials Science:
3,4-Dimethoxyphthalic acid has been studied for its potential applications in materials science, where it may contribute to the development of advanced materials with unique properties and performance characteristics.
Used as a Reagent in Organic Chemical Reactions:
In organic chemistry, 3,4-dimethoxyphthalic acid is used as a reagent to facilitate various chemical reactions, enhancing the efficiency and selectivity of these processes.

InChI:InChI=1/C10H10O6/c1-15-6-4-3-5(9(11)12)7(10(13)14)8(6)16-2/h3-4H,1-2H3,(H,11,12)(H,13,14)

Upstream product

• 569-31-3 meconin 
• 64-17-5 ethanol 
• 519-05-1 opianic acid 
• 5701-87-1 3,4-dimethoxyanthranilic acid 
• 131-28-2 Narcein 
• 10421-76-8 noscapine 
• 70946-11-1 N,N-diethyl 2-carboxy-3,4-dimethoxybenzamide 
• 70946-00-8 N,N-diethyl 2-carboxy-5,6-dimethoxybenzamide 
• 7697-37-2 nitric acid 
• 76202-53-4 (Z)-N-methylhydrastine 
• 7705-08-0 iron(III) chloride 
• 858749-17-4 7,8-dimethoxy-benz[d][1,2]oxazin-1-one 
• 7664-93-9 sulfuric acid 
• 4741-58-6 4,5-dimethoxyisobenzofuran-1(3H)-one 

Downstream Products

• 32255-87-1 dimethyl 3,4-dimethoxy-1,2-benzenedicarboxylate 
• 959007-19-3 3,4-dimethoxy-phthalic acid-1-methyl ester 
• 128823-80-3 3,4-dimethoxy-1,2-benzenedicarboxylic acid 2-methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 645-08-9 Isovanillic acid 
• 632-77-9 1.2.5.8.-tetrahydroxyanthraquinone 
• 17418-07-4 1,2-dimethoxy-3,4,5-trinitrobenzene 
• 82784-82-5 3,4-dihydroxyphthalic acid 
• 72517-27-2 2,3-dimethoxy-5,6-dinitro-benzoic acid 
• 72517-26-1 2,3-dimethoxy-6-nitrobenzoic acid 
• 6279-83-0 3,4-dimethoxy-6-nitro-phthalic acid 
• 872814-86-3 3-hydroxy-4-methoxy-phthalic acid 
• 81241-95-4 5-chloro-3,4-dimethoxy-phthalic acid 
• 81-61-8 1,2,5,8-tetrahydroxy-anthraquinone 

Relevant academic research and scientific papers

CEREBLON E3 LIGASE INHIBITORS

The present disclosure provides compounds represented by Formula I: wherein R2a, R2b, R2c, R2d, R3, R13, and Z are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are cereblon (CRBN) ubiquitination inhibitors or monofunctional synthetic intermediates that can be used to prepare PROTAC molecules. CRBN ubiquitination inhibitors and PROTAC molecules are useful for the treatment of cancer and other diseases.

Competition of substituents for ortho direction of metalation of veratric acid

LTMP (5 equiv) metalates randomly veratric acid (1). Under external quench conditions, the thermodynamically more stable lithium 2-lithio-3,4-dimethoxybenzoate (2) reacts with a variety of electrophiles to give versatile building units that are not easily accessible by conventional means. Under in situ quench conditions (LTMP/TMSCl), a reversal of regioselectivity is observed and 6-trimethylsilyl-3,4-dimethoxybenzoic acid (10) is formed predominantly.

Synthesis and biological activity of C-3' ortho dihydroxyphthalimido cephalosporins

A series of C-3' ortho dihydroxyphthalimido cephalosporins 3~7 has been prepared by reaction of C-3' aminomethyl cephalosporin 411) with the corresponding N carboethoxyphthalimides 23 ~ 25, 37, 38. These new caphalosporins exhibit excellent in vitro Gram-negative activities, including Pseudomonas aeruginosa, excellent β-lactamases stability and pharmacokinetics equivalent or better than ceftriaxone.

Directed ortho metalation of n,n-diethyl benzamides. Methodology and regiospecific synthesis of useful contiguously tri- and tetra-substituted oxygenated aromatics, phthalides and phthalic anhydrides

Full experimental details for the directed ortho metalation approch to a variety of simple ortho-substituted N,N-diethyl benzamides (Table 1) and contiguously 1,2,3- and 1,2,3,4-substituted benzamides (Tables 2) are given. The efficient conversion of these benzamides (6, 10, 12, 13, 18, 19) into phthalides (9a-b, 16b-c, 17) and phthalic anhydrides (8,16a), compounds previously available by demanding, classical methods, is detailed. A short synthesis of iso-ochracinic acid (27) is described.