64877-04-9 Usage
General Description
2-(butylamino)-N-(4-sulfamoylphenyl)acetamide, also known as amsacrine, is a synthetic chemical compound with potential antineoplastic and antileukemic activities. As an acridine derivative, it functions as a topoisomerase II inhibitor, blocking the ligation of DNA double-strand breaks, leading to the accumulation of cytotoxic supercoiled DNA. Amsacrine also intercalates into DNA, preventing normal reannealing and thereby disrupting DNA replication and RNA synthesis. 2-(butylamino)-N-(4-sulfamoylphenyl)acetamide has been investigated for use in the treatment of various cancers, including leukemia and lymphoma, and as a potential radiosensitizer. However, its use is limited due to its potential for cardiotoxicity and myelosuppression, as well as other adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 64877-04-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,8,7 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64877-04:
(7*6)+(6*4)+(5*8)+(4*7)+(3*7)+(2*0)+(1*4)=159
159 % 10 = 9
So 64877-04-9 is a valid CAS Registry Number.
64877-04-9Relevant articles and documents
Programming A Molecular Relay for Ultrasensitive Biodetection through 129XeNMR
Wang, Yanfei,Roose, Benjamin W.,Philbin, John P.,Doman, Jordan L.,Dmochowski, Ivan J.
, p. 1733 - 1736 (2016)
A supramolecular strategy for detecting specific proteins in complex media by using hyperpolarized 129Xe NMR is reported. A cucurbit[6]uril (CB[6])-based molecular relay was programmed for three sequential equilibrium conditions by designing a two-faced guest (TFG) that initially binds CB[6] and blocks the CB[6]-Xe interaction. The protein analyte recruits the TFG and frees CB[6] for Xe binding. TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthesized in one or two steps. X-ray crystallography confirmed TFG binding to Zn2+ in the deep CAII active-site cleft, which precludes simultaneous CB[6] binding. The molecular relay was reprogrammed to detect avidin by using a different TFG. Finally, Xe binding by CB[6] was detected in buffer and in E.coli cultures expressing CAII through ultrasensitive 129XeNMR spectroscopy.
