64879-64-7

Upstream product

• 119784-01-9 5,2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'4'-dideoxy-5-epi-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 64879-65-8 3',4'-dideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 933-40-4 cycloxexanone dimethyl ketal 

Downstream Products

• 119784-00-8 2''-O-benzoyl-4'',6''-O-cyclohexylidene-3'4'-dideoxy-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 119783-73-2 C₅₃H₆₆FN₅O₁₇S₅ 
• 119783-72-1 5,3',4'-Trideoxy-5-fluorokanamycin B 0.8 carbonate 
• 119784-02-0 2''-O-benzoyl-4'',6''-O-cyclohexylidene-5,3',4'-trideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 119783-70-9 C₅₉H₇₄FN₅O₁₇S₅ 
• 119784-00-8 2''-O-benzoyl-4'',6''-O-cyclohexylidene-3'4'-dideoxy-5-epi-1,3,2',6',3''-penta-N-tosylkanamycin B 

Relevant academic research and scientific papers

Synthesis of 5-deoxy-5-fluoro and 5-deoxy-5,5-difluoro derivatives of kanamycin B and its analogs. Study on structure-toxicity relationships

5-Deoxy-5-fluoro- (1), 5,3'-dideoxy-5-fluoro- (2), and 5,3',4'-trideoxy-5-fluoro-kanamycin B (3) have been prepared by treatment of 5-epihydroxyl precursors (prepared by the Mitsunobu reaction) with DAST as the key step. 5,3'-Dideoxy-5,5-difluoro- (26) an

A synthesis of 3',4'-dideoxykanamycin B.

3',4',-Dideoxykanamycin B, the kanamycin B derivative that is active against resistant bacteria, was prepared from kanamycin B via N-tosylation, 3',4'-O-sulphonylation, 3',4'-unsaturation, and hydrogenation. The unsaturated intermediate was obtained from the 3',4'-di-O-sulphonyl derivatives by the action of sodium iodide in N,N-dimethylformamide; if zinc dust was added in this reaction, aziridine derivatives were formed. Removal of the tosyl group was successfully performed by using sodium in ammonia-ethylamine.