64879-65-8

Basic information

• Product Name: 3',4'-dideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B
• CAS NO: 64879-65-8
• Molecular Weight: 1222.47
• Mol File: 64879-65-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3',4'-dideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-dideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B(64879-65-8)
• EPA Substance Registry System: 3',4'-dideoxy-5-fluoro-1,3,2',6',3''-penta-N-tosylkanamycin B(64879-65-8)

Safety Data

• Hazardous Substances Data: 64879-65-8(Hazardous Substances Data)

Downstream Products

• 119784-00-8 2''-O-benzoyl-4'',6''-O-cyclohexylidene-3'4'-dideoxy-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 64879-64-7 4'',6''-O-cyclohexylidene-3'4'-dideoxy-1,3,2',6',3''-penta-N-tosylkanamycin B 
• 190430-66-1 2''-O-acetyl-4'',6''-O-benzylidene-1,3,2',6',3''-penta-N-tosyldibekacin 

Relevant articles and documents

A synthesis of 3',4'-dideoxykanamycin B.

3',4',-Dideoxykanamycin B, the kanamycin B derivative that is active against resistant bacteria, was prepared from kanamycin B via N-tosylation, 3',4'-O-sulphonylation, 3',4'-unsaturation, and hydrogenation. The unsaturated intermediate was obtained from the 3',4'-di-O-sulphonyl derivatives by the action of sodium iodide in N,N-dimethylformamide; if zinc dust was added in this reaction, aziridine derivatives were formed. Removal of the tosyl group was successfully performed by using sodium in ammonia-ethylamine.