6488-64-8Relevant academic research and scientific papers
Chemical components from Metapanax delavayi leaves and their anti-BHP activities in vitro
Sun, Chongzhi,Wu, Yang,Jiang, Bei,Peng, Ying,Wang, Mengyue,Li, Jiaxun,Li, Xiaobo
, p. 56 - 60 (2019/02/15)
Two previously undescribed oleanane-type triterpene saponins named liangwanosides III–IV, and one undescribed eudesmane glycoside named liangwanoside A were obtained from the leaves of Metapanax delavayi, a Chinese folk medicine especially for tea used in Yunnan, together with four known compounds. The structures of the undescribed compounds were determined by detailed spectroscopic (1D/2D NMR), HR-ESI-MS data analysis and chemical evidence. The activity against human benign prostate hyperplasia was evaluated with BPH-1 cell line. Most of the isolated compounds showed moderate inhibitory activity against BPH-1 cells at 100 and 50 μM in vitro.
New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation
Zhu, Yu-Yao,Qian, Li-Wu,Zhang, Jian,Liu, Ji-Hua,Yu, Bo-Yang
experimental part, p. 4206 - 4211 (2011/07/08)
Microbial transformation of 4 olean-type pentacyclic triterpenes (OPTs), 3-oxo oleanolic acid (1), 3-acetyl oleanolic acid (2), oleanolic acid (3), and esculentoside A (4) was studied. After the screening of 12 strains of microbes, preparative biotransformation by two strains of Streptomyces griseus ATCC 13273 and Aspergillus ochraceus CICC 40330 resulted in the isolation of 10 metabolites. The microbial catalyzed high efficient regio-selective methyl oxidation and glycosylation were discovered, which could be provided as an alternative method to expand the structural diversity of OPTs. All the structures of the metabolites were elucidated unambiguously by ESI-MS, 1H NMR, 13C NMR, and 2D-NMR spectroscopy.
