64880-92-8

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 64-04-0 phenethylamine 
• 50-00-0 formaldehyd 
• 52374-24-0 N-(4-nitrobenzenesulfonyl)-2-phenylethylamine 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 6346-00-5 2-(2-hydroxyethyl)benzyl alcohol 
• 89-51-0 Homophthalic acid 

Downstream Products

• 7252-02-0 2-((4-aminophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 1615201-21-2 (1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol 
• 1615201-22-3 2-((4-(4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 1615201-43-8 2-((4-azidophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 1615201-24-5 2-((4-(4-((o-tolyloxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 1615201-25-6 2-((4-(4-((p-tolyloxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline 
• 1615201-26-7 1-(2-((1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethanone 
• 1615201-27-8 methyl 2-((1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzoate 
• 1615201-28-9 4-((1-(4-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)phenyl)-1H-1,2,3-triazol-4-yl)methoxy)benzaldehyde 

Relevant academic research and scientific papers

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

Abstract A series of 1,4-disubstituted-1,2,3-triazoles (13-35) containing sulfonamide moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles with open-chain sulfonamide showed significant aromatase inhibitory activity

Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies

A novel series of 1,4-naphthoquinones (33-44) tethered by open and closed chain sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and antimalarial activities. All quinone-sulfonamide derivatives displayed a broad spectrum o

Practical and cost-effective manufacturing route for the synthesis of a β-lactamase inhibitor

Compound 1, a potent and irreversible inhibitor of β-lactamases, is in clinical trials with β-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.

Design, synthesis and molecular docking studies of novel N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-based triazoles with potential anticancer activity

A novel series of N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinolines (14-33) containing triazole moiety were designed and synthesized through rational cycloadditions using the modified Pictet-Spengler reaction and the Click chemistry. Antiproliferative act

In vitro and in vivo antileishmanial and trypanocidal studies of new N -benzene- and N -naphthalenesulfonamide derivatives

We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N-substituted benzene and naphthalenesulfonamides 1-15. Compounds 1-15 were screened in vitro against Leishmania infantum, Leishmania braziliensis, Leishmania gu

A facile synthesis of 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole and other pyrrolidine-fused aromatic ring systems via one-step cyclization from diols

A facile synthetic method of 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole, which is a subunit of a potent factor Xa (fXa) inhibitor was developed. This new approach employs one-step cyclization from a diol and can be applied to the syntheses of other pyrrolidine-fused aromatic ring sytems.