648869-68-5Relevant academic research and scientific papers
A facile one-pot synthesis of acyclic β-enamino ketones, an important class of versatile synthetic intermediates
Choudhury, Anusuya,Breslav, Michael,Grimm, Jeffrey S.,Xiao, Tong,Xu, Dawei,Sorgi, Kirk L.
, p. 3069 - 3072 (2008/02/02)
A one-pot sequential process consisting of nucleophilic substitution of the lithiated acetylides with Weinreb amides followed by a Michael reaction of the extruded N-methoxy-N-methylamine after quenching with saturated NH4Cl, provided β-enamino ketones in high yield and in a single geometrical isomeric form. It has been demonstrated that this method is applicable to a wide variety of such amides and to different acetylides.
CCK-1 RECEPTOR MODULATORS
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Page/Page column 249, (2010/02/10)
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: (I) wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, and methods of making the same.
CCK-1 RECEPTOR MODULATORS
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Page 248-249, (2008/06/13)
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
