648894-30-8

Basic information

• Product Name: methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate
• Synonyms: methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate
• CAS NO: 648894-30-8
• Molecular Weight: 608.672
• Mol File: 648894-30-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate(648894-30-8)
• EPA Substance Registry System: methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate(648894-30-8)

Safety Data

• Hazardous Substances Data: 648894-30-8(Hazardous Substances Data)

Upstream product

• 6366-06-9 1-(3,5-dimethylphenyl)acetylene 
• 486406-56-8 methyl 2-{4-amino-3-[(3,5-dimethylphenyl)ethynyl]phenyl}-2-methyl-propanoate 
• 486406-54-6 4-(3,5-dimethylphenyl)-2-methylbut-3-yn-2-ol 
• 1656-44-6 2,4-dinitrobenzenesulfonyl chloride 

Downstream Products

• 100-43-6 4-vinylpyridine 

Relevant articles and documents

Enantiospecific and regioselective opening of 2-alkyl nosylaziridines by indoles mediated by boron trifluoride. Application to a practical synthesis of a GnRH antagonist

An efficient, high yield process for the synthesis of a GnRH antagonist has been developed. We have demonstrated that under boron trifluoride mediation, nosyl aziridines will react with 2-arylindole derivatives to afford β-substituted tryptamines in an enantiospecific process with remarkably high regioselectivity. The scope of the reaction was explored with several 2-substituted nosyl aziridines. The key reaction was developed expressly for the GnRH antagonist program and has been demonstrated on 40 kilogram scale.