6366-06-9

Basic information

• Product Name: 1-ETHYNYL-3,5-DIMETHYL-BENZENE
• Synonyms: 1-ETHYNYL-3,5-DIMETHYL-BENZENE;Benzene, 1-ethynyl-3,5-dimethyl- (9CI);3,5-DiMethylphenylacetylene
• CAS NO: 6366-06-9
• Molecular Formula: C₁₀H₁₀
• Molecular Weight: 130.1864
• Mol File: 6366-06-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 206.3°C at 760 mmHg
• Flash Point: 66.8°C
• Appearance: /
• Density: 0.93g/cm³
• Vapor Pressure: 0.343mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 1-ETHYNYL-3,5-DIMETHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYNYL-3,5-DIMETHYL-BENZENE(6366-06-9)
• EPA Substance Registry System: 1-ETHYNYL-3,5-DIMETHYL-BENZENE(6366-06-9)

Safety Data

• Hazardous Substances Data: 6366-06-9(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Odor

Strong

Uses

Industrial solvent, chemical intermediate, building block in synthesis of pharmaceuticals, dyes, and perfumes

Flammability

Flammable

Health hazards

Skin and eye irritation upon direct contact

Safety precautions

Proper handling and storage to prevent accidents or health hazards

InChI:InChI=1/C10H10/c1-4-10-6-8(2)5-9(3)7-10/h1,5-7H,2-3H3

Upstream product

• 61172-35-8 1-(1-chlorovinyl)-3,5-dimethylbenzene 
• 556-96-7 5-bromo-1,3-xylene 
• 1066-54-2 trimethylsilylacetylene 
• 486406-54-6 4-(3,5-dimethylphenyl)-2-methylbut-3-yn-2-ol 
• 22445-41-6 3,5-dimethylphenyl iodide 
• 5779-95-3 3,5-dimethylbenzaldehyde 
• 5379-16-8 3,5-dimethylacetophenone 
• 499-06-9 3,5-dimethylbenzoic acid 
• 276856-72-5 3,5-dimethyl-1-(trimethylsilylethynyl)benzene 

Downstream Products

• 923026-50-0 4-(3,5-dimethylphenyl)-1-[(3-phenylprop-2-yn-1-yl)oxy]but-3-yn-2-one 
• 1449688-01-0 2-(3,5-dimethylphenyl)benzofuran-4-ol 
• 1422465-04-0 2-(4-(3,5-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl)-6-methylpyridine 
• 1338236-30-8 C₁₉H₁₈O 
• 1255533-05-1 1-iodo-8-(3,5-dimethylphenylethynyl)naphthalene 
• 1217356-44-9 5,6-bis(3,5-dimethylphenylethynyl)acenaphthene 
• 1041416-92-5 1,2,5,6-tetrakis(3,5-dimethylphenylethynyl)corannulene 
• 63648-52-2 cuprous 3,5-dimethylphenylacetylide 
• 648894-30-8 methyl 2-[2-(3,5-dimethylphenyl)-3-((1S)-1-methyl-2-{[(2,4-nitrophenyl)sulfonyl]amino}ethyl)-1H-indol-5-yl]-2-methylpropanoate 
• 853021-65-5 ethyl 2-(3,5-dimethylphenyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-8-carboxylate 

Relevant articles and documents

Synthesis of Phenanthrenes via Palladium-Catalyzed Three-Component Domino Reaction of Aryl Iodides, Internal Alkynes, and o-Bromobenzoic Acids

A new palladium-catalyzed domino alkyne insertion/C-H activation/decarboxylation sequence has been developed, which provides an efficient approach for synthesizing a variety of functionalized phenanthrenes in moderate to good yields. The method shows broad substrate scope and good functional group tolerance by employing readily available materials, including aryl iodides, internal alkynes, and o-bromobenzoic acids, as three-component coupling partners.

Calcium carbide catalytically activated with tetra-: N -butyl ammonium fluoride for Sonogashira cross coupling reactions

We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.

The Synthesis of Certain Phomentrioloxin A Analogues and Their Evaluation as Herbicidal Agents

A series of 28 analogues of the phytotoxic geranylcyclohexentriol (-)-phomentrioloxin A (1) has been synthesized through cross-couplings of various enantiomerically pure haloconduritols or certain deoxygenated derivatives with either terminal alkynes or borylated alkenes. Some of these analogues display modest herbicidal activities, and physiological profiling studies suggest that analogue 4 inhibits photosystem II in isolated thylakoids in vitro.