648903-98-4Relevant academic research and scientific papers
Synthesis of tetra- and pentasaccharides corresponding to the capsular polysaccharide of Streptococcus pneumoniae type 9A&L, 9N and 9A
Alpe, Mia,Oscarson, Stefan
, p. 2605 - 2609 (2007/10/03)
Two tetrasaccharides, α-D-GlcAp-(1→3)-α-D-Galp-(1→3)- β-D-ManpNAc-(1→4)-β-D-Glcp and α-D-GlcAp-(1→3)- α-D-Glcp-(1→3)-β-D-ManpNAc-(1→4)-β-D-Glcp (protected form), and a pentasaccharide, α-D-Glcp-(1→4)-α-D-GlcAp- (1→3)-α-D-Galp-(1→3)-β-D-ManpNAc-(1→4)-β-D-Glcp have been synthesised from 2-aminoethyl glycoside trisaccharide acceptors in a linear approach via consecutive α-glycosylations. Ethyl thioglycosides were used as glycosyl donors and DMTST in Et2O or NIS/TfOH in CH 2Cl2 were employed as promoters.
