6494-31-1

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Imidazolidinedione, 1-(4-fluorophenyl)is used as an anticonvulsant for the treatment of epilepsy due to its potential to control seizures and reduce the frequency of epileptic episodes.
Used in Neurological Disorders Treatment:
In the field of neurology, 2,4-Imidazolidinedione, 1-(4-fluorophenyl)is used as a potential treatment for neuropathic pain and other neurological disorders, leveraging its ability to modulate pain signals and alleviate discomfort.
Used in Oncology Research:
2,4-Imidazolidinedione, 1-(4-fluorophenyl)is used as a potential therapeutic agent in oncology research for the treatment of certain types of cancer. Its anticancer properties are currently under investigation to understand its full potential and mechanism of action in combating cancer cells.

Upstream product

• 1345028-76-3 C₁₀H₉FN₂O₂ 
• 658-13-9 p-fluorobenzoyl cyanide 

Downstream Products

• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 
• 1314745-34-0 2-azido-1-(4-fluorophenyl)-4-chloro-1H-imidazole-5-carbaldehyde 
• 1314745-26-0 1-(4-fluorophenyl)-2,4-dichloro-1H-imidazole-5-carbaldehyde 
• 1596360-44-9 methyl 6-[[3-(4-fluorophenyl)-2,5-dioxo-imidazolidin-1-yl]methyl]-7-methyl-pyrrolo[2,3-d]pyrimidine-2-carboxylate 

Relevant academic research and scientific papers

Preparation method for D, L-phenylglycine and analogue thereof

The invention provides a preparation method for D, L-phenylglycine and an analogue thereof. According to the method, benzaldehyde, an analogue thereof and hydrocyanic acid are adopted as raw materials and subjected to cyanidation reaction, and then 2-hydroxy-benzyl cyanide or 2-hydroxy-benzyl cyanide analogue (cyanohydrin for short) is generated. Cyanohydrin reacts with carbon dioxide and the aqueous solution of ammonia, and then 5-phenyl-hydantoin and an analogue thereof (hydantoin for short) are generated. hydantoin is successively subjected to steam stripping, alkaline hydrolysis, steam stripping, decolorization, neutralization, crystallization, washing, centrifuging, drying and the like to obtain D, L-phenylglycine and the analogue thereof. Compared with the prior art, the preparation method for D, L-phenylglycine and the analogue thereof can significantly and effectively reduce the pollution, and fewer inorganic salt by-products are generated. Meanwhile, the prepared D, L-phenylglycine and the analogue thereof are high in product yield and high in purity. Counted in benzaldehyde and the analogue thereof, the yield of D, L-phenylglycine and the analogue thereof is larger than or equal to 96%, and the product purity is larger than or equal to 99%. Meanwhile, the process flow is simple and feasible, so that the method is worthy of market popularization and application.

Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions

Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis-hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. Single crystal structures of some of the representative compounds are also reported.