658-13-9

Usage

Uses

Used in Organic Synthesis:
(4-FLUORO-PHENYL)-OXO-ACETONITRILE is used as a building block in organic synthesis for the creation of a variety of pharmaceuticals and fine chemicals. Its unique structure allows for versatile reactions and the formation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-FLUORO-PHENYL)-OXO-ACETONITRILE serves as a key intermediate in the development of new drugs. Its properties make it a valuable component in the synthesis of potential therapeutic agents.
Used in Agrochemical Production:
(4-FLUORO-PHENYL)-OXO-ACETONITRILE is also utilized in the production of agrochemicals, including insecticides. Its role in these applications is attributed to its ability to contribute to the effectiveness of such products in controlling pests.
Used in Chemical Reactions:
Due to the presence of the fluorine atom, (4-FLUORO-PHENYL)-OXO-ACETONITRILE is involved in a wide range of chemical reactions, making it a versatile compound in the field of chemistry. Its reactivity and stability in various conditions contribute to its broad applications.

InChI:InChI=1/C8H4FNO/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4H

Upstream product

• 462-06-6 fluorobenzene 
• 1115-12-4 carbonyl cyanide 
• 459-22-3 4-fluorophenylacetonitrile 
• 403-43-0 4-fluorobenzoyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 133721-87-6 2-(4-fluorophenyl)-2-hydroxyacetonitrile 
• 74-90-8 hydrogen cyanide 
• 544-92-3 copper(I) cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 456-22-4 4-Fluorobenzoic acid 
• 6494-31-1 1-(4-fluorophenyl)imidazolidine-2,4-dione 
• 89549-76-8 cyano(4-fluorophenyl)methyl benzoate 
• 1443017-27-3 3-(adamantan-1-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole 
• 1443017-31-9 3-cyclohexyl-5-(4-fluorophenyl)-1,2,4-oxadiazole 
• 96898-35-0 5-(4-fluorophenyl)-3-(4-nitrophenyl)-1,2,4-oxadiazole 
• 421581-70-6 5-(4-fluorophenyl)-3-(3-nitrophenyl)-1,2,4-oxadiazole 
• 1443017-24-0 5-(4-fluorophenyl)-3-(2-nitrophenyl)-1,2,4-oxadiazole 
• 378217-59-5 5-(4-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole 
• 836662-41-0 5-(4-fluorophenyl)-3-(3-methoxyphenyl)-1,2,4-oxadiazole 
• 1443017-22-8 5-(4-fluorophenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole 
• 401580-43-6 5-(4-fluorophenyl)-3-phenyl-1,2,4-oxadiazole 
• 78482-28-7 5-(4-Fluoro-phenyl)-2,2-dimethyl-4-methylsulfanyl-2,5-dihydro-oxazol-5-ol 

Relevant academic research and scientific papers

Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction

Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcohols have been developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides or esters in moderate to excellent yields. This approach features a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity, and the potential for further transformation of the cyano group.

Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source

Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones by the reactions of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides is described. The salient features of this protocol are the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance, and simple work-up procedure. (Figure presented.).

Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes

A highly efficient enantioselective hydrogenation of 1,2-dicyanoalkenes catalyzed by the complex of rhodium and f-spiroPhos has been developed. A series of 1,2-dicyanoalkenes were successfully hydrogenated to the corresponding chiral 1,2-dicyanoalkanes under mild conditions with excellent enantioselectivities (up to 98% ee). This methodology provides efficient access to the asymmetric synthesis of chiral diamines.

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

Preparation method for D, L-phenylglycine and analogue thereof

The invention provides a preparation method for D, L-phenylglycine and an analogue thereof. According to the method, benzaldehyde, an analogue thereof and hydrocyanic acid are adopted as raw materials and subjected to cyanidation reaction, and then 2-hydroxy-benzyl cyanide or 2-hydroxy-benzyl cyanide analogue (cyanohydrin for short) is generated. Cyanohydrin reacts with carbon dioxide and the aqueous solution of ammonia, and then 5-phenyl-hydantoin and an analogue thereof (hydantoin for short) are generated. hydantoin is successively subjected to steam stripping, alkaline hydrolysis, steam stripping, decolorization, neutralization, crystallization, washing, centrifuging, drying and the like to obtain D, L-phenylglycine and the analogue thereof. Compared with the prior art, the preparation method for D, L-phenylglycine and the analogue thereof can significantly and effectively reduce the pollution, and fewer inorganic salt by-products are generated. Meanwhile, the prepared D, L-phenylglycine and the analogue thereof are high in product yield and high in purity. Counted in benzaldehyde and the analogue thereof, the yield of D, L-phenylglycine and the analogue thereof is larger than or equal to 96%, and the product purity is larger than or equal to 99%. Meanwhile, the process flow is simple and feasible, so that the method is worthy of market popularization and application.

Reactions of Zirconocene-1-Aza-1,3-diene Complexes with Acyl Cyanides: Substrate-Dependent Synthesis of Acyl- or Non-Acyl-Substituted Pyrroles

Insertion of acyl cyanides into azazirconacyclopentenes derived from 1,3-azadienes has been described, which affords acyl- or non-acyl-substituted pyrroles upon acidic quenching. These reactions are initialized through C=O insertion into the azazirconacycle to afford seven-membered oxaazazirconacycles. In the cases of 1,4- or 1,2,4-substituted azadienes, addition of a second molecule of acyl cyanide followed by cyclization upon acidic quenching leads to acyl-substituted pyrroles. In the cases of 1,3,4-substituted azadienes, the addition of a second molecule of acyl cyanide cannot proceed due to the steric hindrance caused by the R3 group on the zirconium intermediate. Acidic quenching of the resulting zirconium intermediate affords non-acyl-substituted pyrroles.

Synthesis of benzoyl cyanide through aerobic photooxidation of benzyl cyanide using carbon tetrabromide as a catalyst

We developed a synthetic method toward benzoyl cyanide through aerobic photooxidation of benzyl cyanide in the presence of carbon tetrabromide under visible light irradiation with fluorescent lamps.

Synthesis of α,β-Unsaturated and Other Reactive Acyl Cyanides

Reaktive aliphatische Acylcyanide (1 - 10, siehe Tab. 1) werden aus Acylchloriden, Natriumiodid und Kupfer(I)-cyanid unter verschiedenen Bedingungen dargestellt.Die Reaktion verlaeuft ueber die Acyliodide.