64949-90-2

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 25683-09-4 3-(triphenylmethylthio)-alanine 
• 2799-07-7 S-trityl-L-cysteine 

Downstream Products

• 1159004-62-2 NTA(Cys(Trt)OEt)3 
• 1422967-07-4 C₂₆H₂₃N₅O₅S 
• 1422967-06-3 C₂₈H₂₇N₅O₅S 
• 64949-92-4 N-[2-(2-benzoylamino-ethyl)-thiazole-4-carbonyl]-cysteine ethyl ester 

Relevant academic research and scientific papers

Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging

Development of a 99mTc-fatty acid analogue is of interest, as 99mTc is logistically advantageous over the cyclotron-produced 11C and 123I. Synthesis of a 16 carbon fatty acid derivative and its radiolabeling with the novel [99mTcN(PNP)]2+ core is described here. Hexadecanedioic acid was conjugated to cysteine in an overall yield of 55%. This ligand could be labeled with 99mTc via the [99mTcN(PNP)]2+ core, in 80% yield, as a mixture of two isomers (syn and anti). The major isomer isolated by HPLC was used for bioevaluation studies in swiss mice and compared with radioiodinated iodophenyl pentadecanoic acid (IPPA), an established agent for myocardial metabolic imaging. 99mTc-labeled complex cleared faster from the non-target organs, namely, liver, lungs, and blood compared to that of [125I]-IPPA. However, the complex exhibited lower uptake and faster washout from the myocardium as compared to [125I]-IPPA.

RADIOTRACER PRECURSOR FOR IMAGING OF HYPOXIC TISSUE, RADIOTRACER, AND METHOD FOR PREPARING THE SAME

A radiotracer precursor for imaging of hypoxic tissues, a radiotracer and a method for preparing the same are revealed. The radiotracer precursor, DANI, includes a nitroimidazole functional group with a feature of retention in hypoxic tissues and a bifunc

Preparation and evaluation of a 99mTcN-PNP complex of sanazole analogue for detecting tumor hypoxia

A sanazole derivative, having a favorable single electron reduction potential (SERP) value compared to that of misonidazole, was synthesized and radiolabeled with [99mTcN(PNP)] precursor to evaluate its potential as a hypoxia imaging agent. The complex, which was lipophilic, could be prepared in good yields and challenging studies with cysteine showed stability of the complex against trans-chelation. However, despite being lipophilic as well as possessing favorable SERP value, biodistribution studies of this complex in fibrosarcoma tumor bearing Swiss mice showed low uptake in tumor. This observation is possibly attributed to fast clearance of the complex from blood, whereby the complex spends insufficient time in tumor to get reduced and trapped. Though uptake in tumor was low, slow clearance of activity from tumor suggests reduction and trapping of the complex in hypoxic cells. The present 99mTc-complex demonstrated acceptable values of tumor to blood (TBR) and tumor to muscle (TMR) ratios. However, low uptake in tumor which may not be indicative of the actual hypoxic status of the tumor, limit the utility of the complex to detect tumor hypoxia.