25683-09-4

Usage

Uses

Used in Pharmaceutical Research:
(R)-2-amino-3-(tritylthio)propanoic acid is used as a building block in the pharmaceutical industry for the synthesis of various pharmaceuticals and biochemicals. Its unique structure and functional groups contribute to the development of novel compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, (R)-2-amino-3-(tritylthio)propanoic acid is utilized as a key component in the creation of complex organic molecules. Its versatile structure allows for a range of reactions and modifications, making it a valuable asset in the synthesis of diverse chemical compounds.
Used in Medicinal Chemistry:
(R)-2-amino-3-(tritylthio)propanoic acid is employed as a subject of study in medicinal chemistry due to its potential therapeutic applications. Its anti-inflammatory and anti-cancer properties are of particular interest, as they may lead to the development of new treatments for various diseases and disorders.
Used in Drug Development:
(R)-2-aMino-3-(tritylthio)propanoic acid is also used in drug development as a starting material or intermediate for the synthesis of new drugs. Its unique properties and reactivity make it a promising candidate for the creation of innovative pharmaceuticals with improved efficacy and reduced side effects.

Upstream product

• 76-84-6 triphenylmethyl alcohol 
• 32443-99-5 D-cysteine hydrochloride 
• 76-83-5 trityl chloride 
• 10318-18-0 DL-cysteine hydrochloride 
• 921-01-7 D-cysteine 

Downstream Products

• 103841-72-1 p-nitrobenzyl N-p-nitrobenzyloxycarconyl-(R)-cysteinate 
• 910544-76-2 2(R)-(2,2,3,3,3-pentafluoropropylamino)-3-tritylsulfanylpropionic acid 
• 880762-37-8 2(R)-[2,2,2-trifluoro-1(S)-(4-fluorophenyl)ethylamino]-3-tritylsulfanyl-propionic acid 
• 1094039-27-6 (S)-2-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutylamino)-3-(tritylthio)-propanoic acid 
• 1412450-85-1 C₅₈H₅₀N₂O₈S₂ 
• 1431429-92-3 C₃₇H₃₁N₃O₈S 
• 1176235-11-2 (S)-methyl 2-((E)-3-(4-(dimethylamino)phenyl)acrylamido)-3-(tritylthio)propanoate 
• 1246010-90-1 (S)-methyl 2-((E)-3-(2-hydroxynaphthalen-6-yl)acrylamido)-3-(tritylthio)propanoate 
• 1176235-35-0 (S)-methyl 2-((E)-3-(3-acetoxyphenyl)acrylamido)-3-(tritylthio)propanoate 
• 1176235-04-3 (S)-methyl 2-((2E,4E)-5-(4-(dimethylamino)phenyl)penta-2,4-dienamido)-3-(tritylthio)propanoate 
• 115545-85-2 (S)-2-amino-3-(tritylmercapto)propionic acid methyl ester 

Relevant academic research and scientific papers

Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents

By carrying out structural modifications based on the bicyclic peptide structure of echinomycin, we successfully synthesized various powerful antitumor derivatives. The ring conformation in the obtained compounds was restricted by cross-linking with an unnatural bond. The prepared derivatives were demonstrated to strongly suppress the hypoxia inducible factor (HIF)-1 transcriptional activation and hypoxia induction of HIF-1 protein expression. Particularly, alkene-bridged derivative 12 exhibited remarkably potent cytotoxicity (IC50 = 0.22 nM on the MCF-7 cell line) and HIF-1 inhibition (IC50 = 0.09 nM), which considerably exceeded those of echinomycin. Conformational analyses and molecular modeling studies revealed that the biological activities were enhanced following restriction of the conformation by cross-linking through a metabolically stable and rigid bridge bond. In addition, we proposed a new globular conformation stabilized by intramolecular πstacking that can contribute to the biological effects of bicyclic depsipeptides. The developments presented in the current study serve as a useful guide to expand the chemical space of peptides in drug discovery.

Aminothiol compound, preparation method of aminothiol compound and application of aminothiol compound in radiation protection

The invention discloses an aminothiol compound, a preparation method of the aminothiol compound and application of the aminothiol compound in radiation protection. The compound has a structure shown in the formula I in the description, wherein A1 is selected from -C(O)NR8-, -S(O)2-NR8-, -S(O)NR8- and -R7-NR8-, A2 is selected from carbonyl, sulfonyl, sulfinyl and substituted or unsubstituted C1-6 alkyl, R1, R2, R5 and R6 can be the same or not and are selected from hydrogen and substituted or unsubstituted C1-C5 alkyl or hetero alkyl, n is an integer from 0 to 20000, R3 and R4 are independently selected from hydrogen, X and substituted or unsubstituted C1-6 alkyl, X is selected from F, Cl, Br and I, R7 is selected from substituted or unsubstituted C1-C6 alkyl, and R8 is selected from hydrogen and substituted or unsubstituted C1-C6 alkyl. The compound has the effect of reducing biological injury caused by ionizing radiation and also has the effects of prolonging the lifetime of radiated animals and increasing the survival rate of the radiated animals.

seco-Cyclothialidines: New concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties

seco-Cyclothialidines are a promising class of bacterial DNA gyrase B subunit inhibitors. A new seco-cyclothialidine derivative containing a dioxazine moiety, BAY 50-7952, was synthesized through a new concise pathway. One key step of the synthesis is the