64951-98-0

Upstream product

• 63592-79-0 methyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-α-D-ribo-hexopyranoside 
• 90761-25-4 methyl 3-O-benzyl-4,6-O-benzylideno-2-deoxy-α-D-ribo-hexoside 
• 97-30-3 methyl-alpha-D-glucopyranoside 
• 497-19-8 sodium carbonate 
• 6752-48-3 methyl 2-deoxy-4,6-O-benzylidene-α-D-ribo-hexopyranoside 
• 63598-31-2 methyl 4,6-O-(R)-benzylidene-2-deoxy-α-D-erythrohexopyranosid-3-ulose 

Downstream Products

• 82300-39-8 methyl 3-O-benzyl-6-O-trityl-2-deoxy-α-D-ribo-hexopyranoside 
• 151130-44-8 methyl 3-O-benzyl-6-O-t-butyldiphenylsilyl-2-deoxy-α-D-ribo-hexopyranoside 
• 82300-41-2 methyl 3-O-benzyl-4-O-tosyl-2-deoxy-α-D-ribo-hexopyranoside 
• 82300-44-5 methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D-erythro-hexopyranoside 
• 90691-43-3 (2S,4R,6S)-(E)-6-<2-(4'-fluoro-3,3',5-trimethyl<1,1'-biphenyl>-2-yl)ethenyl>-4-(benzyloxy)-2-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 82300-43-4 methyl 3-O-benzyl-6-O-tosyl-2,4-dideoxy-α-D-erythro-hexopyranoside 
• 82300-40-1 methyl 3-O-benzyl-4-O-tosyl-6-O-trityl-2-deoxy-α-D-ribo-hexopyranoside 
• 82300-42-3 methyl 3-O-benzyl-2,4-dideoxy-α-D-erythro-hexopyranoside 
• 90691-42-2 (2S,4R,6S)-1-(4'-fluoro-3,3',5-trimethyl<1,1'-biphenyl>-2-yl)-2-<4-(benzyloxy)-2-methoxy-3,4,5,6-tetrahydro-2H-pyran-6-yl>ethyl phenyl sulfoxide 
• 100295-49-6 (2R,4R,6S)-(E)-6-<2-(4'-fluoro,3,3',5-trimethyl<1,1'-biphenyl>-2-yl)ethenyl>-4-(benzyloxy)-2-methoxy-3,4,5,6-tetrahydro-2H-pyran 
• 106444-95-5 Dithiocarbonic acid O-((2R,3S,4S,6R)-4-benzyloxy-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-yl) ester S-methyl ester 
• 106444-96-6 Dithiocarbonic acid O-((2R,3S,4S,6S)-4-benzyloxy-6-methoxy-2-trityloxymethyl-tetrahydro-pyran-3-yl) ester S-methyl ester 
• 82300-39-8 methyl 3-O-benzyl-2-deoxy-6-O-triphenylmethyl-D-ribohexopyranoside 
• 63592-82-5 Methyl 3-O-benzyl-2,6-dideoxy-α-D-ribo-hexopyranoside 

Relevant academic research and scientific papers

Deleterious effect of 7-methyl group on glycosylation of 2-naphthols

C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (1). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-napht

The Synthesis of Some Pyrrolidines as Potential Precursors to Retronecine

Methyl β-D-galactopyranoside was converted into methyl 4-azido-3-O-benzyl-6-O-t-butyldiphenylsilyl-2,4-dideoxy-β-D-arabino-hexoside, but subsequent transformation of the anomeric centre into a dithioacetal was unsatisfactory. Alternatively, methyl β-D-galactopyranoside easily gave methyl 4-azido-3,6-di-O-benzyl-2,4-dideoxy-β-D-arabino-hexoside, and this could be transformed by a reductive amination into two pyrrolidines as potential precursors to retronecine. Related chemistry gave (4S,5S,6R)-6-benzyloxy-4-benzyloxymethyl-3-oxa-1-azabicyclooctan-2-one, the structure of which was confirmed by a single-crystal X-ray structure determination. Finally, the synthesis of a potential precursor to heliotridine (an epimer of retronecine), namely methyl 4-azido-3-O-benzyl-6-O-t-butyldiphenylsilyl-2,4-dideoxy-α-D-ribo-hexoside, from methyl α-D-mannopyranoside is reported.

Synthesis and Utilization of the Chiral Synthon Methyl 3-O-Benzyl-2,4,6-trideoxy-6-iodo-α-D-erythro-hexopyranoside in the Synthesis of a Potent HMG-CoA Reductase Inhibitor

Synthesis of the potent HMG-CoA reductase inhibitor 1a has been achieved by utilizing the chiral synthon 2, which was prepared from methyl α-D-glucopyranoside in 12 steps (6 new).A key step in this sequence, which should have general applicability for the

PROCESS FOR PREPARING INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE VIA A CHIRAL SYNTHON

Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.