64952-07-4Relevant academic research and scientific papers
Process for the preparation of imidazolidine-2, 4-diones
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, (2008/06/13)
A process for the preparation of compounds of the general formula (I) by reacting an aldehyde compound of the general formula (II) with a urea compound of the general formula (III) in the presence of carbon monoxide and a catalytically active metal compound. Compounds of the general formula (I) are important intermediates for the synthesis of α-amino acids.
Palladium-catalyzed synthesis of substituted hydantoins - A new carbonylation reaction for the synthesis of amino acid derivatives
Beller, Matthias,Eckert, Markus,Moradi, Wahed A.,Neumann, Helfried
, p. 1454 - 1457 (2007/10/03)
One-step synthesis of substituted hydantoins can be achieved by the palladium-catalyzed 'ureidocarbonylation' of aldehydes with urea derivatives and carbon monoxide [Eq. (1)]. This surprisingly selective protocol converts substituted ureas into 1,5- and 1,3,5-substituted hydantoins in yields of up to 93 %.
