6617-78-3

Basic information

• Product Name: 5-(4-METHOXYPHENYL)HYDATOIN
• Synonyms: 5-(4-METHOXYPHENYL)HYDATOIN;5-(4-Methoxyphenyl)-2,4-imidazolidinedione
• CAS NO: 6617-78-3
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.198
• Mol File: 6617-78-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.273g/cm³
• Refractive Index: 1.554
• CAS DataBase Reference: 5-(4-METHOXYPHENYL)HYDATOIN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXYPHENYL)HYDATOIN(6617-78-3)
• EPA Substance Registry System: 5-(4-METHOXYPHENYL)HYDATOIN(6617-78-3)

Safety Data

• Hazardous Substances Data: 6617-78-3(Hazardous Substances Data)

Usage

General Description

5-(4-Methoxyphenyl)hydantoin, also known as methsuximide, is a chemical compound used as an anticonvulsant medication. It is a derivative of hydantoin and is structurally related to phenytoin. Methsuximide works by suppressing abnormal electrical activity in the brain, making it effective in treating certain types of seizures, particularly absence seizures. It is available in tablet form for oral administration and is typically taken multiple times a day. Methsuximide may cause side effects such as dizziness, drowsiness, and upset stomach, and it is important to discuss any potential interactions with other medications with a healthcare provider before taking it.

InChI:InChI=1/C10H10N2O3/c1-15-7-4-2-6(3-5-7)8-9(13)12-10(14)11-8/h2-5,8H,1H3,(H2,11,12,13,14)

Upstream product

• 173904-10-4 5-bromohydantoin 
• 100-66-3 methoxybenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 52287-67-9 N-[(4-methoxyphenyl)(tosyl)methyl]urea 
• 2393-23-9 4-methoxy-benzylamine 
• 42456-26-8 2-amino-2-(4-methoxyphenyl)acetonitrile 
• 124-38-9 carbon dioxide 
• 506-87-6 ammonium carbonate 
• 76986-15-7 2-amino-2-(4-methoxyphenyl)acetamide 
• 33646-40-1 4-methoxymandelonitrile 
• 151-50-8 potassium cyanide 
• 119-52-8 4,4'-dimethoxybenzoin 
• 79-11-8 chloroacetic acid 
• 590-28-3 potassium cyanate 

Downstream Products

• 170119-36-5 Methoxycarbonylamino-(4-methoxy-phenyl)-acetic acid 
• 1443523-50-9 5-(4-methoxyphenyl)-5-(3-methylbut-2-enyl)-3-phenylmethyl-2,4-imidazolidinedione 
• 1443523-44-1 3-benzyl-5-(4-methoxyphenyl)hydantoin 
• 1015231-54-5 C₂₆H₁₄F₆N₄O₃ 
• 60781-72-8 DL-α-Benzyloxycarbonylamino-(4-methoxy-phenyl)-essigsaeure 
• 2540-53-6 2-(4-methoxyphenyl)glycine 
• 64952-07-4 5-cyclohexyl-hydantoin 

Relevant articles and documents

Different pathways in the reaction of N-(tosylmethyl)-substituted ureas, thioureas, and N′-cyanoguanidines with sodium cyanide. Synthesis of α-ureido nitriles, α-ureido amides, and hydantoin imino derivatives

Reaction of N-(tosylmethyl)-substituted ureas, thioureas, and N′-cyanoguanidines, prepared by condensation of the corresponding amides with various aldehydes and p-toluenesulfinic acid, with NaCN has been studied. The outcome of the reaction is strongly d

A one-pot synthesis of 5,5-disubstituted hydantoin derivatives using magnetic Fe3O4 nanoparticles as a reusable heterogeneous catalyst

A facile and rapid method for the one-pot synthesis of 5,5-disubstituted hydantoins in the presence of magnetic Fe3O4 nanoparticles has been developed. The multicomponent reactions of carbonyl compounds (aldehydes and ketones), potassium cyanide and ammonium carbonate were carried out under solvent-free conditions to obtain various hydantoin derivatives. The magnetic catalyst could be readily separated by an external magnet from the reaction mixture. This procedure has many advantages, such as the use of a reusable magnetic catalyst, high yields, short reaction times, simplicity and very easiness with implementing the methodology.

Ruthenium catalyzed hydroaminoalkylation of isoprene via transfer hydrogenation: Byproduct-free prenylation of hydantoins

The ruthenium catalyst derived from Ru3(CO)12 and triphos [Ph2P(CH2CH2PPh2) 2] promotes the direct C-C coupling of isoprene with aryl substituted hydantoins 1a-1f at the diene C4-position to furnish products of n-prenylation 2a-2f. A mechanism involving hydantoin dehydrogenation followed by diene-imine oxidative coupling to furnish a transient aza-ruthencyclopentene is proposed.