649557-56-2

Upstream product

• 1415829-27-4 (Z)-4-(4-cyanophenyl)-2-hydroxy-4-oxobut-2-enoic acid ethyl ester 
• 1443-80-7 4-cyanophenyl methyl ketone 
• 649557-55-1 ethyl 4-(4-cyanophenyl)-2,4-dioxobutanoate 

Downstream Products

• 649557-57-3 ethyl 3-(4-cyanophenyl)-1-[2-(tetrahydro-2H-pyran-2-yloxv)-ethyl]-1H-pyrazole-5-carboxylate 
• 1277168-01-0 C₁₁H₇N₃O₂ 
• 1415829-28-5 ethyl 3-(4-cyanophenyl)-1-methyl-1H-pyrazole-5-carboxylate 
• 934605-59-1 C₁₃H₁₀ClN₃O₂ 

Relevant academic research and scientific papers

Design and synthesis of novel ditopic ligands with a pyrazole ring in the central unit

Four novel ditopic ligands that have a pyrazole ring in their central unit and are useful for the generation of coordination polymers have been synthesized. Two of these ditopic ligands present two carboxylate functions as coordinating groups, while the o

NITROGEN-CONTAINING HETEROCYCLIC AMIDE COMPOUND AND PHARMACEUTICAL USE THEREOF

PROBLEM TO BE SOLVED: To provide a nitrogen-containing heterocyclic amide compound having pyruvate dehydrogenase kinase inhibitory activity, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. SOLUTION: The present invention provides a compound of formula [I-a] or formula [II], or a pharmaceutically acceptable salt thereof (a bond of a dotted line: a single bond or a double bond. X1: C, N, O. X2: C, N. R1a: C1-4 alkyl, C1-4 alkyl carbonyl. R2: halogen, cyano, C1-4 alkyl. A1-A7: C, N, O. A8: C, N. R3, R4: H, C1-4 alkyl. Cy1: C4-6 cycloalkyl or the like. Cy2: C3-6 cycloalkyl or the like. m, t, w: 0, 1. n, r, v: 0, 1, 2.) SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor

A series of 3-aryl-5-acylpiperazinyl-pyrazoles (e.g., 3a-b) initially identified through a high-throughput screening campaign using the aequorin Ca2+ bioluminescence assay as novel, potent small molecule antagonists of the G protein-coupled hum

ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA

This invention relates to novel compounds which up-regulate LDL receptor (LDL-r) expression and to processes for their preparation, pharmaceutical compositions containing them and their medical use. More particularly, this invention relates to novel aromatic piperidines of formula (I) and their use in therapy.