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1-Veratryl-piperidine-2-carboxylic acid ethyl ester, also known as VP-EE, is a chemical compound with the molecular formula C16H23NO3. It is a derivative of piperidine, a heterocyclic amine, and is characterized by the presence of a veratryl group (3,4-dimethoxybenzyl) attached to the nitrogen atom. This ester is a white crystalline solid that is soluble in organic solvents. VP-EE is primarily used as a protecting group in organic synthesis, particularly in the preparation of peptides and other nitrogen-containing compounds. It serves to temporarily block the amine group, preventing unwanted side reactions and facilitating the synthesis of complex molecules. The ester group in VP-EE can be selectively removed under mild acidic conditions, allowing for the controlled deprotection of the amine. This makes it a valuable tool in the field of medicinal chemistry and drug development.

6496-16-8

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6496-16-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6496-16-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,9 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6496-16:
(6*6)+(5*4)+(4*9)+(3*6)+(2*1)+(1*6)=118
118 % 10 = 8
So 6496-16-8 is a valid CAS Registry Number.

6496-16-8Downstream Products

6496-16-8Relevant academic research and scientific papers

Reductive amination of piperidines with aldehydes using borane-pyridine

Moormann

, p. 789 - 795 (1993)

Borane-pyridine complex (BAP) was found to be an excellent replacement for NaCNBH3 in the Borch reduction. Assorted aromatic, heterocyclic and aliphatic aldehydes were reacted with various substituted piperidines using standardized conditions.

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