64965-48-6

Basic information

• Product Name: 3-IODO-QUINOLIN-4-OL
• Synonyms: 3-IODO-QUINOLIN-4-OL;4-Quinolinol, 3-iodo-;3-iodo-4-Quinolinol
• CAS NO: 64965-48-6
• Molecular Formula: C₉H₆INO
• Molecular Weight: 271.05451
• Mol File: 64965-48-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-IODO-QUINOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-QUINOLIN-4-OL(64965-48-6)
• EPA Substance Registry System: 3-IODO-QUINOLIN-4-OL(64965-48-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 64965-48-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-IODO-QUINOLIN-4-OL is used as a pharmaceutical compound for its antimalarial, antibacterial, antifungal, and anticancer properties. Its diverse range of applications makes it a valuable candidate for the development of new drugs and treatments in the pharmaceutical industry.
Used in Antimalarial Applications:
3-IODO-QUINOLIN-4-OL is used as an antimalarial agent, targeting the Plasmodium parasites responsible for malaria. Its effectiveness in treating this disease makes it a potential candidate for inclusion in antimalarial drug formulations.
Used in Antibacterial Applications:
3-IODO-QUINOLIN-4-OL is used as an antibacterial agent, capable of inhibiting the growth of various bacteria. This property makes it a potential candidate for the development of new antibiotics to combat bacterial infections.
Used in Antifungal Applications:
3-IODO-QUINOLIN-4-OL is used as an antifungal agent, effective against a range of fungi. Its antifungal properties make it a potential candidate for the development of new antifungal drugs to treat fungal infections.
Used in Anticancer Applications:
3-IODO-QUINOLIN-4-OL is used as an anticancer agent, targeting cancer cells and inhibiting their growth. Its potential in cancer treatment makes it a promising candidate for further research and development in the field of oncology.

InChI:InChI=1S/C9H6INO/c10-7-5-11-8-4-2-1-3-6(8)9(7)12/h1-5H,(H,11,12)

Upstream product

• 855633-99-7 4-hydroxy-3-iodo-quinoline-2-carboxylic acid ethyl ester 
• 24782-43-2 ethyl 4-hydroxyquinoline-2-carboxylate 
• 855634-00-3 4-hydroxy-3-iodo-quinoline-2-carboxylic acid 
• 611-36-9 quinolin-4-ol 

Downstream Products

• 1449680-34-5 2-phenylfuro[3,2-c]quinoline 
• 1449680-40-3 2-phenylfuro[3,2-c]quinolin-4-amine 
• 1449680-37-8 2-phenylfuro[3,2-c]quinoline 5-oxide 
• 1268468-60-5 3-(4-methoxy-phenyl)-4-(2-methyl-tetrahydro-furan-3-ylsulfanyl)-quinoline 

Relevant articles and documents

AZABICYCLIC(THIO)AMIDES AS FUNGICIDAL COMPOUNDS

The present invention relates to azabicyclic (thio)amide compounds and the uses thereof for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds

TOLL-LIKE RECEPTOR 8 AGONISTS

Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for therapies were being a TLR8 agonist is useful. The pharmac

Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines

Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds may be promising candidate adjuvants. We synthesized and evaluated hitherto unexplored furo[2,3-c]quinolines and regioisomeric furo[3,2-c]quinolines derived via a tandem, one-pot Sonogashira coupling and intramolecular 5-endo-dig cyclization strategy in a panel of primary screens. We observed a pure TLR8-agonistic activity profile in select furo[2,3-c] quinolines, with maximal potency conferred by a C2-butyl group (EC50 = 1.6 μM); shorter, longer, or substituted homologues as well as compounds bearing C1 substitutions were inactive, which was rationalized by docking studies using the recently described crystal structure of human TLR8. The best-in-class compound displayed prominent proinflammatory cytokine induction (including interleukin-12 and interleukin-18), but was bereft of interferon-α inducing properties, confirming its high selectivity for human TLR8.

A simple method for iodination of heterocyclic compounds using HIO 4/NaCl/silica gel/H2SO4 in water

A fast and simple method for iodination of some heterocycles is reported. The reactions were carried out in water, using HIO4/H 2SO4/NaCl/silica gel at moderate temperatures of 25-50 °C. Springer-Verlag 2011.

SUBSTITUTED PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE TO TREAT OXIDATIVE STRESS

Substituted pyridine derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted pyridine derivative, and methods of use in treating inflammation are provided. The substituted pyridine derivatives may control of the act