64967-16-4 Usage
Uses
Used in Oncology:
5-Fluoropyrimidin-2-one beta-ribofuranoside is used as a chemotherapeutic agent for the treatment of various types of cancer, particularly colorectal and liver cancer. It functions by disrupting the synthesis of DNA and RNA in cancer cells, leading to the inhibition of their growth and proliferation.
Used in Cancer Treatment Administration:
In the application of cancer treatment, 5-fluoropyrimidin-2-one beta-ribofuranoside is used as an injectable medication administered directly into the affected area, such as the tumor or the abdominal cavity. This targeted administration allows for a focused treatment approach, increasing the drug's effectiveness against cancerous cells.
However, it is important to note that while 5-fluoropyrimidin-2-one beta-ribofuranoside is effective in treating certain types of cancer, it can also cause side effects such as nausea, vomiting, and bone marrow suppression. These side effects must be carefully managed and monitored during treatment to ensure patient safety and optimal therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 64967-16-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,9,6 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64967-16:
(7*6)+(6*4)+(5*9)+(4*6)+(3*7)+(2*1)+(1*6)=164
164 % 10 = 4
So 64967-16-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H11FN2O5/c10-4-1-11-9(16)12(2-4)8-7(15)6(14)5(3-13)17-8/h1-2,5-8,13-15H,3H2/t5-,6-,7-,8-/m1/s1
64967-16-4Relevant academic research and scientific papers
Antitumor Properties of 2(1H)-Pyrimidinone Riboside (Zebularine) and Its Fluorinated Analogues
Driscoll, John S.,Marquez, Victor E.,Plowman, Jacqueline,Liu, Paul S.,Kelley, James A.,Barchi, Joseph J.
, p. 3280 - 3284 (2007/10/02)
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and evaluated in vivo as antitumor agents.Zebularine provides increase in life span (ILS) values of ca. 70percent against intraperito
