64967-39-1

Basic information

• Product Name: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine
• Synonyms: N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU-OH;[(2S, 3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE;Glycine, N-3-(2-furanyl)-1-oxo-2-propenyl-L-phenylalanylglycyl-;2-furanacryloyl-phenylalanyl-glycyl-glycine
• CAS NO: 64967-39-1
• Molecular Formula: C₂₀H₂₁N₃O₆
• Molecular Weight: 399.4
• EINECS: 261-529-2
• Product Categories: Enzyme substrates
• Mol File: 64967-39-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 245 °C (dec.)(lit.)
• Boiling Point: 842.3 °C at 760 mmHg
• Flash Point: 463.2 °C
• Appearance: OFF-WHITE TO LIGHT TAN POWDER
• Density: 1.321 g/cm³
• Vapor Pressure: 3.9E-30mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: −20°C
• Solubility: NH4OH 1 M: 50 mg/mL, clear to slightly turbid, yellow
• PKA: 3.32±0.10(Predicted)
• CAS DataBase Reference: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(64967-39-1)
• EPA Substance Registry System: N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine(64967-39-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: OH2915000
• Hazardous Substances Data: 64967-39-1(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 64967-39-1 differently. You can refer to the following data:
1. A substrate for the continuous sprectrophotometric assay of ACE.
2. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly has been used for kinetic spectrophotometric assay of ACE (angiotensin converting enzyme) inhibitory activity.

General Description

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly acts as a substrate for angiotensin converting enzyme (ACE), and is used in inhibitory assays of ACE.

InChI:InChI=1/C20H21N3O6/c24-17(9-8-15-7-4-10-29-15)23-16(11-14-5-2-1-3-6-14)20(28)22-12-18(25)21-13-19(26)27/h1-10,16H,11-13H2,(H,21,25)(H,22,28)(H,23,24)(H,26,27)/b9-8+/t16-/m0/s1

Upstream product

• 539-47-9 3-(fur-2-yl)crotonic acid 
• 4526-84-5 N^α-benzyloxycarbonylphenylalanylglycylglycine ethyl ester 
• 67998-15-6 (E)-3-(furan-2-yl)acrylic anhydride 
• 2440-94-0 quinolin-8-yl ester of N-benzyloxycarbonyl-L-phenylalanine 
• 103972-53-8 N^α-furylacryloylphenylalanylglycylglycine ethyl ester 

Relevant articles and documents

SYNTHESIS OF N-FURYLACRYLOYL DERIVATIVES OF AMINO ACIDS AND PEPTIDES, CHROMOGENIC SUBSTRATES OF PROTEOLYTIC ENZYMES, USING FURYLACRYLIC ACID ANHYDRIDE

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