64970-80-5Relevant academic research and scientific papers
A Facile Synthesis of a Key Intermediate for (+)-Biotin via Strecker Reaction
Mori, Yoshikazu,Kimura, Mayumi,Seki, Masahiko
, p. 2311 - 2316 (2007/10/03)
The Strecker reaction of (2R,4R)-2-phenyl-3-phenoxycarbonylthiazolidine-4- carbaldehyde (4b), which was readily prepared from L-cysteine, with benzylamine and trimethylsilyl cyanide provided α-amino nitrile 5b stereoselectively (syn-anti, 2:1), Amidation of 5b and subsequent cyclization gave bicyclic compound 6, which, upon reduction with zinc dust, hydrolysis and subsequent cyclization, furnished thiolactone 2, a key intermediate for (+)-biotin (1).
