649724-99-2Relevant academic research and scientific papers
Benzothiophene and naphthalene derived constrained SERMs
Wallace, Owen B.,Bryant, Henry U.,Shetler, Pamela K.,Adrian, Mary D.,Geiser, Andrew G.
, p. 5103 - 5106 (2004)
The synthesis and biological evaluation of two series of conformationally restricted SERMs are disclosed. In each series (benzothiophene or naphthalene), the ligand side chain is constrained to adopt a defined orientation. The orientation of the side chain has a significant impact on functional activity.
DIHYDRO-DIBENZO[B,E]OXEPINE BASED SELECTIVE ESTROGEN RECEPTOR MODULATORS, COMPOSITIONS AND METHODS
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Page 25, (2008/06/13)
The present invention provides a compound of the formula (I) wherein R1 is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C2-C6
