649725-43-9

Upstream product

• 219692-15-6 (3,5-dibromo-4-(5-isopropyl-4-methoxy-phenoxy)-phenyl)-acetic acid methyl ester 
• 649725-42-8 methyl[3,5-dibromo-4-(5-isopropyl-4-methoxy-3-nitrophenoxy)phenyl]acetate 

Downstream Products

• 649725-46-2 L-methyl-N-[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenylacetyl]valinate 
• 649725-45-1 methyl[3,5-dibromo-4-(3-fluoro-5-isopropyl-4-methoxyphenoxy)phenyl]acetic acid 

Relevant academic research and scientific papers

Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141

Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of novel N-acylated-α-amino acid derivatives were synthesized and tested in a TR radioligand binding assay as well as in a repor

NOVEL COMPOUNDS

This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunctio