649725-44-0Relevant academic research and scientific papers
Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141
Garg, Neeraj,Li, Yi-Lin,Garcia Collazo, Ana Maria,Litten, Chris,Ryono, Denis E.,Zhang, Minsheng,Caringal, Yolanda,Brigance, Robert P.,Meng, Wei,Washburn, William N.,Agback, Peter,Mellstroem, Karin,Rehnmark, Stefan,Rahimi-Ghadim, Mahmoud,Norin, Thomas,Grynfarb, Marlena,Sandberg, Johnny,Grover, Gary,Malm, Johan
, p. 4131 - 4134 (2008/02/13)
Based on the scaffold of the pharmacologically selective thyromimetic 2b, structurally a close analog to KB-141 (2a), a number of novel N-acylated-α-amino acid derivatives were synthesized and tested in a TR radioligand binding assay as well as in a repor
