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649736-29-8

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  • ethyl 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

    Cas No: 649736-29-8

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649736-29-8 Usage

Description

Methyl 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate is a complex organic chemical compound characterized by a unique molecular structure. It features a methyl ester group attached to a pyrrolotriazine ring system, which is a nitrogen-containing heterocyclic ring. Additionally, the compound includes a 4-fluoro-2-methyl-1H-indol-5-yloxy moiety, a substituted indole ring with a fluorine and methyl group. This intricate molecular arrangement may endow the compound with diverse potential applications across various fields, including pharmaceuticals, agrochemicals, and materials science. Further characterization and study are necessary to fully understand its specific properties and uses.

Uses

Used in Pharmaceutical Industry:
Methyl 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate is used as a potential pharmaceutical agent for its unique molecular structure, which may offer novel therapeutic properties. methyl 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate's indole and pyrrolo[1,2-f][1,2,4]triazine components could be leveraged for the development of new drugs targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, methyl 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate may serve as a precursor or active ingredient in the development of new pesticides or herbicides. Its complex structure could provide innovative solutions for pest and weed control, enhancing crop protection and yield.
Used in Materials Science:
Methyl 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carboxylate's heterocyclic ring system and functional groups may contribute to the development of advanced materials with unique properties. It could be utilized in the creation of new polymers, coatings, or other materials with specific characteristics, such as improved stability, conductivity, or responsiveness to environmental stimuli.

Check Digit Verification of cas no

The CAS Registry Mumber 649736-29-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,9,7,3 and 6 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 649736-29:
(8*6)+(7*4)+(6*9)+(5*7)+(4*3)+(3*6)+(2*2)+(1*9)=208
208 % 10 = 8
So 649736-29-8 is a valid CAS Registry Number.

649736-29-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

1.2 Other means of identification

Product number -
Other names QC-1046

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:649736-29-8 SDS

649736-29-8Relevant articles and documents

Commercial synthesis of a pyrrolotriazine-fluoroindole intermediate to brivanib alaninate: Process development directed toward impurity control

Pesti, Jaan A.,LaPorte, Thomas,Thornton, John E.,Spangler, Lori,Buono, Frederic,Crispino, Gerard,Gibson, Frank,Lobben, Paul,Papaioannou, Christos G.

, p. 89 - 102 (2014/05/20)

The development of a practical, commercial process for the preparation of 4-fluoro-2-methyl-indol-5-ol and its subsequent coupling with a pyrrolotriazine to form an advanced intermediate of the oncology therapy brivanib alaninate is described. A key aspect is the multikilogram-scale preparation of the fluoroindole intermediate from trifluoronitrobenzene and the subsequent coupling while achieving impurity minimalization. As brivanib alaninate is a high-dose drug, the synthesis of highquality API with low levels of impurities is critical.

PROCESS FOR PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS

-

Page 31, (2008/06/13)

The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

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