649755-89-5

Upstream product

• 649755-84-0 (Z)-(2R,3S,4S)-2,4-dimethyl-3-triethylsilanyloxyocta-5,7-dienal 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 
• 649755-77-1 (3R,4S,5S)-3,5-dimethyl-4-[(triethylsilanyl)oxy]tetrahydropyran-2-one 

Downstream Products

• 649755-90-8 (R)-4-benzyl-3-[(Z)-(2R,3S,4R,5S,6S)-3-(tert-butyldimethylsilanyloxy)-2,4,6-trimethyl-5-triethylsilanyloxydeca-7,9-dienoyl]-oxazolidin-2-one 
• 649755-87-3 (Z)-(2R,3S,4R,5S,6S)-3-(tert-butyldimethylsilanyloxy)-2,4,6-trimethyl-5-triethylsilanyloxydeca-7,9-dienethioic acid S-benzyl ester 

Relevant academic research and scientific papers

A formal synthesis of (+)-discodermolide

Herein, we report the formal synthesis of (+)-discodermolide (1), a promising anticancer agent of sponge origin, in 24 linear steps, with 35 steps in total. The route proceeds from lactone 2, a building block containing the common 1,2-anti-2,3-syn stereot

SYNTHESIS OF DISCODERMOLIDE

The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae