649767-17-9Relevant academic research and scientific papers
A phosphoarginine containing peptide as an artificial SH2 ligand
Hofmann, Frank T.,Lindemann, Claudia,Salia, Helen,Adamitzki, Philipp,Karanicolas, John,Seebeck, Florian P.
, p. 10335 - 10337 (2011/11/12)
We have developed a synthesis of phosphoarginine containing peptides using a bis(2,2,2-trichloroethyl) protected phosphoarginine derivative as building block. Binding studies and computer modelling demonstrate the ability of the SH2 domain from Src kinase to recognize a phosphoarginine-containing peptide in a phosphoryl group-dependent manner.
