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6498-04-0

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6498-04-0 Usage

General Description

1,2,4-Triazine-3-carboxylic acid is a heterocyclic organic compound with the chemical formula C4H3N3O2. It is a derivative of 1,2,4-triazine, containing a carboxylic acid functional group. 1,2,4-Triazine-3-carboxylic acid has potential applications in the pharmaceutical industry, as it is a core structure found in some biologically active molecules. It is also used in the field of material science for the synthesis of novel functional materials. Additionally, 1,2,4-triazine-3-carboxylic acid has been studied for its potential antimicrobial and anti-inflammatory properties, making it of interest for research in the field of medicine. Overall, this chemical compound has diverse potential applications and is the subject of ongoing research in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 6498-04-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,9 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6498-04:
(6*6)+(5*4)+(4*9)+(3*8)+(2*0)+(1*4)=120
120 % 10 = 0
So 6498-04-0 is a valid CAS Registry Number.

6498-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,4-TRIAZINE-3-CARBOXYLIC ACID

1.2 Other means of identification

Product number -
Other names 1.2.4-Triazin-3-carbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6498-04-0 SDS

6498-04-0Relevant articles and documents

1,2,4-Triazine-Modified 2′-Deoxyuridine Triphosphate for Efficient Bioorthogonal Fluorescent Labeling of DNA

Peewasan, Krisana,Wagenknecht, Hans-Achim

, p. 1473 - 1476 (2017/08/09)

In order to establish the Diels–Alder reaction with inverse electron demand for postsynthetic DNA modification, a 1,2,4-triazine-modified 2′-deoxyuridine triphosphate was synthesized. The bioorthogonally reactive 1,2,4-triazine group was attached at the 5-position of 2′-deoxyuridine by a flexible alkyl linker to facilitate its acceptance by DNA polymerases. The screening of four DNA polymerases showed successful primer extensions, using a mixture of dATP, dGTP, dCTP, and the modified 2′-deoxyuridine triphosphate, by using KOD XL or Vent polymerase. The triazine moiety was stable under the conditions of primer extension, which was evidenced by labeling with a BCN-modified rhodamine at room temperature in yields of up to 82 %. Two or three modified bases could be incorporated in quantitative yields when the modification sites were separated by three base pairs. These results establish the 1,2,4-triazene group as a bioorthogonally reactive moiety in DNA, thereby replacing the problematic 1,2,4,5-tetrazine for postsynthetic labeling by the Diels–Alder reaction with inverse electron demand.

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