6498-04-0

Basic information

• Product Name: 1,2,4-TRIAZINE-3-CARBOXYLIC ACID
• Synonyms: 1,2,4-TRIAZINE-3-CARBOXYLIC ACID;SODIUM 1,2,4-TRIAZINE-3-CARBOXYLATE
• CAS NO: 6498-04-0
• Molecular Formula: C₄H₃N₃O₂
• Molecular Weight: 125.08552
• Product Categories: Heterocycles series;Carboxylic Acids;Carboxylic Acids;Ring Systems
• Mol File: 6498-04-0.mol

Chemical Properties

• Boiling Point: 402.6 °C at 760 mmHg
• Flash Point: 197.3 °C
• Appearance: /
• Density: 1.532 g/cm³
• PKA: 2.35±0.10(Predicted)
• CAS DataBase Reference: 1,2,4-TRIAZINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-TRIAZINE-3-CARBOXYLIC ACID(6498-04-0)
• EPA Substance Registry System: 1,2,4-TRIAZINE-3-CARBOXYLIC ACID(6498-04-0)

Safety Data

• Hazardous Substances Data: 6498-04-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,2,4-Triazine-3-carboxylic acid is used as a core structure in the development of biologically active molecules for the pharmaceutical industry. Its presence in certain compounds contributes to their therapeutic effects, making it a valuable component in the creation of new drugs.
Used in Material Science:
In the field of material science, 1,2,4-triazine-3-carboxylic acid is utilized for the synthesis of novel functional materials. Its unique chemical properties allow for the engineering of materials with specific characteristics, such as improved stability or reactivity, for various applications.
Used in Medical Research:
1,2,4-Triazine-3-carboxylic acid is studied for its potential antimicrobial and anti-inflammatory properties in the field of medicine. Its ability to combat microbial infections and reduce inflammation makes it a promising candidate for further research and development in medical treatments.
Overall, 1,2,4-triazine-3-carboxylic acid is a versatile chemical compound with a wide range of potential applications. Its ongoing research and development in different fields highlight its significance and potential impact on various industries.

Upstream product

• 6498-02-8 ethyl 1,2,4-triazine-3-carboxylate 

Downstream Products

• 290-38-0 1,2,4-triazine 
• 1193371-19-5 C₁₈H₁₉N₃O₂ 
• 1193371-14-0 C₂₇H₂₇N₃O₂ 

Relevant articles and documents

1,2,4-Triazine-Modified 2′-Deoxyuridine Triphosphate for Efficient Bioorthogonal Fluorescent Labeling of DNA

In order to establish the Diels–Alder reaction with inverse electron demand for postsynthetic DNA modification, a 1,2,4-triazine-modified 2′-deoxyuridine triphosphate was synthesized. The bioorthogonally reactive 1,2,4-triazine group was attached at the 5-position of 2′-deoxyuridine by a flexible alkyl linker to facilitate its acceptance by DNA polymerases. The screening of four DNA polymerases showed successful primer extensions, using a mixture of dATP, dGTP, dCTP, and the modified 2′-deoxyuridine triphosphate, by using KOD XL or Vent polymerase. The triazine moiety was stable under the conditions of primer extension, which was evidenced by labeling with a BCN-modified rhodamine at room temperature in yields of up to 82 %. Two or three modified bases could be incorporated in quantitative yields when the modification sites were separated by three base pairs. These results establish the 1,2,4-triazene group as a bioorthogonally reactive moiety in DNA, thereby replacing the problematic 1,2,4,5-tetrazine for postsynthetic labeling by the Diels–Alder reaction with inverse electron demand.

Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion

A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the influence of the substitution