6498-02-8

Basic information

• Product Name: ETHYL 1,2,4-TRIAZINE-3-CARBOXYLATE
• Synonyms: ETHYL 1,2,4-TRIAZINE-3-CARBOXYLATE
• CAS NO: 6498-02-8
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Mol File: 6498-02-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 70 °C
• Boiling Point: 278.0±23.0 °C(Predicted)
• Appearance: /
• Density: 1.239±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.77±0.63(Predicted)
• CAS DataBase Reference: ETHYL 1,2,4-TRIAZINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1,2,4-TRIAZINE-3-CARBOXYLATE(6498-02-8)
• EPA Substance Registry System: ETHYL 1,2,4-TRIAZINE-3-CARBOXYLATE(6498-02-8)

Safety Data

• Hazardous Substances Data: 6498-02-8(Hazardous Substances Data)

Usage

General Description

Ethyl 1,2,4-triazine-3-carboxylate is a chemical compound consisting of a triazine ring with an ethyl ester group attached to the 3-position. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Ethyl 1,2,4-triazine-3-carboxylate has potential applications in the development of new drugs, herbicides, and pesticides. It is important to handle this compound with care, as it may pose health and environmental risks if not used properly. Additionally, it is important to follow safety protocols and regulations when working with this chemical.

Upstream product

• 131543-46-9 Glyoxal 
• 53085-26-0 Oxalsaeureethylesteramidrazon 
• 4845-50-5 2,3-dihydroxy-1,4-dioxane 

Downstream Products

• 72755-19-2 9H-β-carboline-1-carboxylic acid ethyl ester 
• 126422-07-9 Ethyl 5,6-trans-di(3-indolyl)-1,2,5,6-tetrahydro-1,2,4-triazine-3-carboxylate 
• 692729-88-7 ethyl 6,7-dihydro-5H-cyclopenta[c]pyridine-1-carboxylate 
• 96898-18-9 ethyl 4-methyl-3-phenylpyridine-2-carboxylate 
• 52565-57-8 ethyl 4-phenylpyridine-2-carboxylate 
• 96898-21-4 ethyl 3-phenylpyridine-2-carboxylate 
• 123346-80-5 1,3-Dioxo-2-phenyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylic acid ethyl ester 
• 123346-89-4 C₂₆H₂₁N₃O₆ 
• 6498-04-0 1,2,4-triazine-3-carboxylic acid 

Relevant articles and documents

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Synthesis of substituted fused pyridines, pyrazines and pyrimidines by sequential Ugi/inverse electron demand Diels-Alder transformations

The synthesis of all four regioisomers of fused pyrrolidino-pyridines in a one-pot two-step sequential Ugi-inverse electron demand Diels-Alder reaction is described. Fused pyrrolidino-pyrazines, pyrrolidino-pyrimidines and azepinone pyridines can also be obtained in consecutive synthetic sequences.

Indole as a Dienophile in Inverse Electron Demand Diels-Alder Reactions: Reactions with 1,2,4-Triazines and 1,2-Diazines

Indole reacts with 1,2,4-triazines in the absence of solvent or in the presence of limited amounts of solvent to produce β- or γ-carbolines, benzonaphthyridines, or the noncyclized 3-indoles.The combined yields of cycloadducts with tricarbalkoxytriazines exceeds 90 percent, with the production of γ-carbolines exceeding 80 percent.The regiochemistry of the adduct and the ratio of the products is determined mainly by electronic effects of the triazine substituents.Indole also ungergoes a cyclocondensation reaction with tetramethyl 1,2-diazine-3,4,5,6-tetracarboxylate to give trimethyl 5H-6-oxophenanthridine-2,3,4-tricarboxylate.