64982-35-0

Basic information

• Product Name: (3aS,4R,5S,6aR)-hexahydro-5-(biphenyl-4-formyloxy)-4-(tert-butyldimethylsilyloxy methyl)-2H-cyclopenta[b]furan-2-one
• Synonyms: (3aS,4R,5S,6aR)-hexahydro-5-(biphenyl-4-formyloxy)-4-(tert-butyldimethylsilyloxy methyl)-2H-cyclopenta[b]furan-2-one
• CAS NO: 64982-35-0
• Molecular Weight: 466.649
• Mol File: 64982-35-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3aS,4R,5S,6aR)-hexahydro-5-(biphenyl-4-formyloxy)-4-(tert-butyldimethylsilyloxy methyl)-2H-cyclopenta[b]furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,4R,5S,6aR)-hexahydro-5-(biphenyl-4-formyloxy)-4-(tert-butyldimethylsilyloxy methyl)-2H-cyclopenta[b]furan-2-one(64982-35-0)
• EPA Substance Registry System: (3aS,4R,5S,6aR)-hexahydro-5-(biphenyl-4-formyloxy)-4-(tert-butyldimethylsilyloxy methyl)-2H-cyclopenta[b]furan-2-one(64982-35-0)

Safety Data

• Hazardous Substances Data: 64982-35-0(Hazardous Substances Data)

Upstream product

• 39265-57-1 <3aS(3aα,4α,5β,6aα)>-(+)-5-(1,1'-biphenyl-4-carbonyloxy)hexahydro-4-hydroxymethyl-2H-cyclopentafuran-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 76704-05-7 <3aS(3aα,4α,5β,6aα)>-(+)-5-hydroxy-4-hydroxymethyl-hexahydro-2H-cyclopentafuran-2-one 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 58707-50-9 (3aS,4R,5S,6aR)-hexahydro-5-hydroxy-4-(tert-butyldimethylsilyloxymethyl)-2H-cyclopenta[b]furan-2-one 

Downstream Products

• 197523-93-6 (Z)-7-[(1S,2R,3S,5R)-5-Acetoxy-2-hydroxymethyl-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-hept-5-enoic acid methyl ester 

Relevant articles and documents

SYNTHETIC METHOD OF ENTECAVIR AND INTERMEDIATE COMPOUNDS THEREOF

The present invention relates to preparation method of drugs and intermediate compounds thereof, in particular, to preparation method of entecavir, intermediate compounds thereof and synthetic method of said intermediate compounds.

Prostanoids: Synthesis of enantiomers of 15-deoxy-16-hydroxy-16-methylprostaglandin E1

Four optically pure isomers of methyl 11,16-dihydroxy-16-methyl-9-oxoprost-13-enoate (1a-1d) were synthesized using an approach reverse to the classical Corey procedure, the key intermediates being the easily accessible (-)- and (+)-enantiomers of the Corey lactone, 2a and 2b.