64985-95-1

Basic information

• Product Name: (1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine
• CAS NO: 64985-95-1
• Molecular Formula: C₁₆H₁₄F₂N₂
• Molecular Weight: 272.2926
• Mol File: 64985-95-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 327.628°C at 760 mmHg
• Flash Point: 151.944°C
• Density: 1.104g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: (1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine(64985-95-1)
• EPA Substance Registry System: (1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine(64985-95-1)

Safety Data

• Hazardous Substances Data: 64985-95-1(Hazardous Substances Data)

Usage

Description

(1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine is a hydrazone derivative with the molecular formula C16H16F2N2. It features a carbon-nitrogen double bond and two aromatic rings, making it a chemical compound of interest in the field of drug discovery and medicinal chemistry.

Uses

Used in Chemical Research and Synthesis:
(1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine is used as a building block for creating new molecules with potential pharmaceutical or biological activity. Its unique structure and properties make it a valuable component in the development of innovative compounds for various applications.
It is important to handle (1E)-bis[1-(4-fluorophenyl)ethylidene]hydrazine with care, as it may pose health and safety hazards if not used appropriately. Its potential uses and properties make it an interesting target for further study and development in the field of drug discovery and medicinal chemistry.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 93480-06-9 (1-(4-fluorophenyl)ethylidene)hydrazine 
• 75230-49-8 N′-(1-(4-fluorophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 329-79-3 1-(4-fluorophenyl)ethanone oxime 

Relevant articles and documents

Cp*Co(iii)-catalyzed annulation of azines by C-H/N-N bond activation for the synthesis of isoquinolines

Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the synthesis of isoquinolines. Azines were employed for annulation reactions with alkynes via sequential C-H/N-N bond activation using an air-stable cobalt catalyst. The method takes advantage of the incorporation of both the nitrogen atoms of azines into the desired isoquinoline products, offering the highest atom economy. In addition, the developed protocol works under external oxidant as well as silver salt free conditions. Furthermore, the established methodology features a relatively broad substrate scope with high product yields and scalability up to the gram level.

A process for preparing 1, 2 - double-(1 - aryl alkyl methylene) method of the hydrazine compound

The present invention discloses method for preparing a 1,2-bis(1-aralkyl methylene) hydrazine compound. The method comprises the following steps of: dissolving benzene sulfonyl hydrazone into a CH3CN solvent; then adding ammonium persulfate and cesium carbonate to react for 6hours under a condition of 100 DEG C; after the reaction is ended, performing extraction and column chromatographic separation, thereby obtaining the 1,2-bis(1-aralkyl methylene) hydrazine compound. According to the method, ammonium persulfate with a low price is used as a catalyst to catalyze benzene sulfonyl hydrazone to generate degradation reaction; the reaction conditions are mild; the reaction time is short; a post-treatment process is simple; the reaction product is low; and the product yield is high. The 1,2-bis(1-aralkyl methylene) hydrazine compound can be used as a useful synthesis intermediate, and has potential pharmaceutical activity and a wide application.

Copper-catalyzed N-N bond formation by homocoupling of ketoximes via n-o bond cleavage: Facile, mild, and efficient synthesis of azines

A facile, mild, and efficient copper-catalyzed homocoupling of ketoximes involving N-O bond cleavage in the presence of sodium bisulfite (NaHSO has been developed. This reaction shows good functional group tolerance and affords a broad scope of azines in high yields.