64987-06-0

Basic information

• Product Name: (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid
• Synonyms: 4-THIAZOLEACETIC ACID, 2-(FORMYLAMINO)-ALPHA-OXO-;(2-FORMAMIDO-4-THIAZOLYL)GLYOXALIC ACID;2-(2-FORMYLAMINOTHIAZOL-4-YL) GLYOXYLIC ACID;2-(2-FORMYLAMINOTHIAZOL-4-YL) GLYOXYLIC ACID (FTGA);(2-FORMAMIDO-1,3-THIAZOL-4-YL)GLYOXYLIC ACID;4-THIAZOLEACETICACID,2-(FORMYLAMINO)-A-OXO;2-(2-ForMaMido-1,3-thiazol-4-yl)-2-oxoacetic acid;2-(2-Formamidothiazol-4-yl)-2-oxoacetic acid
• CAS NO: 64987-06-0
• Molecular Formula: C₆H₄N₂O₄S
• Molecular Weight: 200.17
• EINECS: 613-733-1
• Product Categories: Organic acids
• Mol File: 64987-06-0.mol

Chemical Properties

• Boiling Point: 406.6 ºC at 760 mmHg
• Flash Point: 199.7 ºC
• Appearance: /
• Density: 1.739 g/cm³
• Vapor Pressure: 2.43E-07mmHg at 25°C
• Refractive Index: 1.692
• PKA: 1.80±0.54(Predicted)
• CAS DataBase Reference: (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid(64987-06-0)
• EPA Substance Registry System: (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid(64987-06-0)

Safety Data

• Hazardous Substances Data: 64987-06-0(Hazardous Substances Data)

Usage

Uses

Used in Synthetic Chemistry:
(2-Formamido-1,3-thiazol-4-yl)glyoxylic acid is used as a building block or intermediate in the synthesis of more complex molecules, particularly in the field of organic chemistry. Its unique functional groups can be exploited to form a variety of chemical bonds, making it a valuable component in the creation of novel compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid may serve as a key component in the development of new drugs. Its structure could potentially be incorporated into drug molecules to enhance their therapeutic effects or to improve their pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion.
Used in Materials Science:
(2-Formamido-1,3-thiazol-4-yl)glyoxylic acid could be utilized in the development of new materials with specific properties, such as improved stability or reactivity. Its incorporation into material compositions may lead to advancements in areas like polymer science, where it could contribute to the creation of materials with tailored characteristics for various applications.

InChI:InChI=1/C6H4N2O4S/c9-2-7-6-8-3(1-13-6)4(10)5(11)12/h1-2H,(H,11,12)(H,7,8,9)

Upstream product

• 64987-03-7 ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate 
• 64987-05-9 ethyl 2-(2-formylaminothiazol-4-yl)acetate 

Downstream Products

• 73150-67-1 2-oxo-2-(2-aminothiazol-4-yl)acetic acid 
• 74771-10-1 2-(2-formamidothiazol-4-yl)-2-(4-aminomethylbenzyloxyimino)acetic acid 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of a New Class of 2-(2-Aminothiazol-4-yl)-2-hydrazonoacetamido Cephalosporins

A series of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins 1a-h was prepared.Whenever possible, E and Z isomers were isolated, and their relative stabilities and their interconversions were tested.The antibacterial activity was tested against Gram-positive and Gram-negative bacteria.For compound 1c, whose Z and E forms do not interconvert rapidly, the Z form was the more active one.Among the other compounds, for which the E form is the only stable one for practical purposes, compound 1a was the most active.When compared with cefuroxime and cefotaxime, compound 1a showed slightly lower antibacterial activity but good serum level and half-life values.

Process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof, and intermediates therefor and process for producing the intermediates

This invention relates to a novel process for producing a 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof which are useful in producing a cephalosporin antibiotic, and to intermediates for said derivative and salt and a process for producing the intermediates.

2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds

Compounds of the formula: STR1 wherein R1 is (C1 to C6) alkyl. R2 is carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6) alkylene, and pharmaceutically acceptable salt thereof, have been found to be active against various pathogenic microorganisms.

2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds

A compound of the formula: STR1 wherein R1 is (C1 to C6) alkyl, R2 is carboxy or a protected carboxy group, R3 is amino or a protected amino group, and A is carbonyl or hydroxy (C1 to C6) alkylene, and pharmaceutically acceptable salt thereof, which is active against pathogenic bacteria, and methods for preparing the same.

2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions

A compound of the formula: STR1 wherein R1 is (C1 to C6) alkyl, R2 is a carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6)alkylene, And pharmaceutically acceptable salt thereof.