64987-06-0Relevant articles and documents
Synthesis and Pharmacological Evaluation of a New Class of 2-(2-Aminothiazol-4-yl)-2-hydrazonoacetamido Cephalosporins
Brandt, Alberto,Cerquetti, Marina,Corsi, G. Bruno,Pascucci, Giorgio,Simeoni, Antonio,et al.
, p. 764 - 767 (2007/10/02)
A series of 2-(2-aminothiazol-4-yl)-2-hydrazonoacetamido cephalosporins 1a-h was prepared.Whenever possible, E and Z isomers were isolated, and their relative stabilities and their interconversions were tested.The antibacterial activity was tested against Gram-positive and Gram-negative bacteria.For compound 1c, whose Z and E forms do not interconvert rapidly, the Z form was the more active one.Among the other compounds, for which the E form is the only stable one for practical purposes, compound 1a was the most active.When compared with cefuroxime and cefotaxime, compound 1a showed slightly lower antibacterial activity but good serum level and half-life values.
Process for producing 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof, and intermediates therefor and process for producing the intermediates
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, (2008/06/13)
This invention relates to a novel process for producing a 2-(2-aminothiazol-4-yl)glyoxylic acid derivative or a salt thereof which are useful in producing a cephalosporin antibiotic, and to intermediates for said derivative and salt and a process for producing the intermediates.
2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds
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, (2008/06/13)
Compounds of the formula: STR1 wherein R1 is (C1 to C6) alkyl. R2 is carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6) alkylene, and pharmaceutically acceptable salt thereof, have been found to be active against various pathogenic microorganisms.
2-Lower alkyl-7-substituted amino-2 or 3-cephem-4-carboxylic acid compounds
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, (2008/06/13)
A compound of the formula: STR1 wherein R1 is (C1 to C6) alkyl, R2 is carboxy or a protected carboxy group, R3 is amino or a protected amino group, and A is carbonyl or hydroxy (C1 to C6) alkylene, and pharmaceutically acceptable salt thereof, which is active against pathogenic bacteria, and methods for preparing the same.
2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions
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, (2008/06/13)
A compound of the formula: STR1 wherein R1 is (C1 to C6) alkyl, R2 is a carboxy or a protected carboxy group, R3 is amino or a protected amino group and A is hydroxyimino (C1 to C6) alkylene or (C1 to C6)-alkoxyimino (C1 to C6)alkylene, And pharmaceutically acceptable salt thereof.